Table 1

 Baseline characteristics of the study population

Glipizide (n = 25)Metformin (n = 59)Placebo (n = 97)p Value
Values are mean (SD).
AoDist, aortic distensibility; BSA, body mass index; DBP, diastolic blood pressure; HDL, high density lipoprotein; LDL, low density lipoprotein; LV, left ventricle; NS, not significant; OGTT, oral glucose tolerance test; SBP, systolic blood pressure; SI, insulin sensitivity index.
Age (years)44.4 (9.0)40.5 (7.0)41.0 (7.0)NS
Men/women11%/89%26%/74%24%/76%NS
Weight (kg)94.6 (25.8)90.5 (20.8)89.9 (22.2)NS
BSA (m2)2.0 (0.3)1.94 (0.2)2.0 (0.2)NS
SBP (mm Hg)133 (22.0)122 (15.0)125.0 (14.0)NS
DBP (mm Hg)82 (11.0)80.0 (11.0)82.1 (10.6)NS
Pulse pressure (mm Hg)50 (15.5)42.8 (12.6)44.2 (11.0)NS
LV mass index (g/m2)129 (35.7)123.0 (23.6)127.0 (29.2)NS
Ascending AoDist (cm2/dyn×10–6)2.5 (1.4)2.8 (1.6)3.2 (1.7)NS
Abdominal AoDist (cm2/dyn×10–6)4.1 (2.5)3.7 (1.5)4.0 (1.5)NS
Pulse wave velocity (m/s)9.9 (2.7)10.1 (1.9)9.6 (2.4)NS
Fasting glucose (mmol/l)4.53 (0.95)4.44 (0.83)4.50 (1.11)NS
120 min glucose OGTT (mmol/l)5.41 (1.40)5.39 (1.0)5.76 (2.04)NS
Fasting insulin (μU/ml)9.7 (5.7)15.2 (7.9)12.8 (9.7)NS
SI (min−1/μU/ml)2.4 (1.5)2.7 (1.7)2.4 (1.5)NS
Fasting C peptide (nmol/l)0.8 (0.4)0.87 (0.4)0.9 (0.5)NS
Total cholesterol (mmol/l)5.0 (0.71)4.69 (0.89)4.64 (0.87)NS
HDL cholesterol (mmol/l)1.39 (0.32)1.12 (0.25)1.28 (0.35)NS
LDL cholesterol (mmol/l)3.08 (0.77)2.89 (0.9)2.76 (0.98)NS
Triglycerides (mmol/l)1.12 (0.7)1.12 (0.69)1.29 (1.75)NS