Table 3

 Changes from baseline in metabolic variables

Δ12Δ24p Value
ANOVAANOVA v placebo
Values are mean (SEM).
Placebo
    Fasting serum glucose (mmol/l)0.18 (0.22)0.10 (0.21)NSNA
    Fasting serum insulin (μU/ml)1.53 (2.22)1.8 (2.26)NSNA
    SI (min−1×μU/ml)0.13 (0.23)0.43 (0.36)NSNA
    Fasting C peptide (nmol/l)−0.17 (0.08)−0.15 (0.09)NSNA
Glipizide
    Fasting serum glucose (mmol/l)−0.43 (0.49)0.19 (0.61)NSNS
    Fasting serum insulin (μU/ml)5.7 (2.1)10.4 (2.7)<0.01NS
    SI (min−1×μU/ml)−0.65 (0.4)−0.94 (0.4)NSNS
    Fasting C peptide (nmol/l)−0.05 (0.13)0.30 (0.17)NSNS
Metformin
    Fasting serum glucose (mmol/l)0.34 (0.25)0.43 (0.28)NSNS
    Fasting serum insulin (μU/ml)2.7 (2.5)2.3 (2.4)NSNS
    SI (min−1×μU/ml)0.1 (0.3)−0.65 (0.4)NSNS
    Fasting C peptide (nmol/l)0.66 (0.51)−0.27 (0.37)NSNS