Changes from baseline in lipid variables
| Δ12 | Δ24 | p Value | ||
|---|---|---|---|---|
| ANOVA | ANOVA v placebo | |||
| Values are mean (SEM). | ||||
| Placebo | ||||
| Total cholesterol (mmol/l) | 0.228 (0.136) | 0.527 (0.118) | <0.001 | NA |
| HDL cholesterol (mmol/l) | 0.127 (0.062) | 0.119 (0.047) | NS | NA |
| LDL cholesterol (mmol/l) | 0.188 (0.161) | 0.326 (0.122) | NS | NA |
| Triglycerides (mmol/l) | −0.189 (0.254) | 0.177 (0.186) | NS | NA |
| Total cholesterol:HDL | 0.17 (1.8) | 0.07 (0.14) | NS | NA |
| Glipizide | ||||
| Total cholesterol (mmol/l) | −0.067 (0.184) | 0.285 (0.168) | NS | NS |
| HDL cholesterol (mmol/l) | 0.041 (0.109) | 0.044 (0.098) | NS | NS |
| LDL cholesterol (mmol/l) | −0.212 (0.207) | 0.168 (0.189) | NS | NS |
| Triglycerides (mmol/l) | 0.226 (0.139) | 0.161 (0.128) | NS | NS |
| Total cholesterol:HDL | 0.1 (0.4) | 0.14 (0.3) | NS | NS |
| Metformin | ||||
| Total cholesterol (mmol/l) | 0.254 (0.137) | 0.179 (0.132) | NS | NS |
| HDL cholesterol (mmol/l) | 0.122 (0.072) | 0.078 (0.067) | NS | NS |
| LDL cholesterol (mmol/l) | 0.298 (0.155) | 0.399 (0.142) | NS | NS |
| Triglycerides (mmol/l) | 0.053 (0.128) | 0.096 (0.119) | NS | NS |
| Total cholesterol:HDL | 0.1 (0.2) | 0.3 (0.1) | NS | NS |