Antibiotic prophylaxis for IE in dental care and upper respiratory tract procedures: administration of antibiotics respecting contraindications and usual conditions of use and surveillance
| Antibiotic | Dosage and route of administration | ||
|---|---|---|---|
| *Oral paediatric dosages: amoxicillin 75 mg/kg; clindamycin 15 mg/kg; pristinamycin 25 mg/kg; †2 g orally if the patient’s weight is <60 kg; ‡the respective percentage of streptococci strains with a decreased susceptibility to these two antibiotics must be taken into account for the choice; §paediatric dosages: amoxicillin 50 mg/kg intravenously (iv) before, 25 mg/kg orally 6 hours later; vancomycin 20 mg/kg (maximum 1 g); teicoplanin: no official approval for antibiotic prophylaxis in children. | |||
| Ambulatory care* | Single dose in the hour before the procedure | ||
| No allergy to β lactams | Amoxicillin | 3 g orally† | |
| Allergy to β lactams | Pristinamycin‡ or | 1 g orally | |
| clindamycin‡ | 600 mg orally | ||
| General anaesthesia§ | Before (in the hour before the procedure) | After (6 hours later) | |
| No allergy to β lactams | Amoxicillin | 2 g iv (infusion 30 min) | 1 g orally |
| Allergy to β lactams | Vancomycin or | 1 g iv (infusion ⩾60 min) | No second dose |
| teicoplanin | 400 mg iv (bolus) | ||