Classification of endothelin converting enzyme inhibitors
| Selective ECE inhibitors | Dual ECE/NEP inhibitors | Triple ECE/NEP/ACE inhibitors |
|---|---|---|
| ACE, angiotensin converting enzyme; ECE, endothelin converting enzyme; NEP, neutral endopeptidase. | ||
| • Natural product | • NEP>ECE | • Potent |
| FR 901532 (WS 79089B) | Phosphoramidon | SCH 54470 |
| B90063 | CGS 26303 | |
| WS 75624B | SLV 306 | |
| • Synthetic compound | • ECE>NEP | • Moderate |
| SM 19712 | CGS 34043 | SA 6817 |
| PD 069185 | CGS26582 | |
| CGS 35066 | ||