Univariate and multivariate (adjusted for covariates listed in table 2) hazard ratios for various characterisations of the anti-huhsp60 titre for the end points
| Covariate | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| NA, not applicable. | ||||
| Hard end point | ||||
| Log (anti-huhsp60) | 1.30 (0.98 to 1.74) | 0.071 | 1.08 (0.80 to 1.46) | 0.61 |
| ⩾90th centile anti-huhsp60 | 1.27 (0.63 to 2.57) | 0.51 | 0.94 (0.45 to 1.94) | 0.86 |
| Anti-huhsp60 quartiles (U/l) | ||||
| <16 | 1.00 | NA | 1.0 | NA |
| ⩾16–<24 | 1.21 (0.57 to 2.53) | 0.62 | 1.18 (0.56 to 2.48) | 0.66 |
| ⩾24–<36 | 1.76 (0.87 to 3.54) | 0.11 | 1.52 (0.75 to 3.07) | 0.25 |
| ⩾36 | 1.82 (0.92 to 3.62) | 0.087 | 1.35 (0.67 to 2.72) | 0.41 |
| Overall p value | 0.24 | 0.69 | ||
| Hard plus soft end point | ||||
| Log (anti-huhsp60) | 1.09 (0.93 to 1.27) | 0.29 | 1.09 (0.93 to 1.28) | 0.28 |
| ⩾90th centile anti-huhsp60 | 0.94 (0.63 to 1.40) | 0.77 | 0.91 (0.61 to 1.37) | 0.66 |
| Anti-huhsp60 quartiles (U/l) | ||||
| <16 | 1.00 | NA | 1.0 | NA |
| ⩾16–<24 | 1.61 (1.14 to 2.26) | 0.0067 | 1.64 (1.16 to 2.32) | 0.0051 |
| ⩾24–<36 | 1.37 (0.96 to 1.95) | 0.086 | 1.41 (0.98 to 2.03) | 0.066 |
| ⩾36 | 1.50 (1.06 to 2.13) | 0.021 | 1.56 (1.09 to 2.23) | 0.015 |
| Overall p value | 0.042 | 0.031 | ||