Univariate and multivariate (adjusted for covariates listed in table 2) hazard ratios for various characterisations of the anti-mhsp65 titre for the end points
| Covariate | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Hard end point | ||||
| Log (anti-mhsp65) | 1.10 (0.86 to 1.40) | 0.47 | 0.95 (0.74 to 1.23) | 0.70 |
| ⩾90th centile anti-mhsp65 | 1.31 (0.65 to 2.64) | 0.45 | 1.02 (0.50 to 2.07) | 0.97 |
| Anti-mhsp65 quartiles (U/l) | ||||
| <9 | 1.0 | NA | 1.0 | NA |
| ⩾9–<17 | 1.61 (0.81 to 3.22) | 0.18 | 1.48 (0.74 to 2.99) | 0.27 |
| ⩾17–<31 | 1.52 (0.75 to 3.11) | 0.25 | 1.23 (0.60 to 2.54) | 0.57 |
| ⩾31 | 1.36 (0.69 to 2.78) | 0.40 | 0.95 (0.46 to 1.97) | 0.90 |
| Overall p value | 0.57 | 0.52 | ||
| Hard plus soft end point | ||||
| Log (anti-mhsp65) | 0.97 (0.86 to 1.10) | 0.63 | 0.97 (0.86 to 1.11) | 0.68 |
| ⩾90th centile anti-mhsp65 | 0.87 (0.58 to 1.32) | 0.52 | 0.87 (0.57 to 1.31) | 0.50 |
| Anti-mhsp65 quartiles (U/l) | ||||
| <9 | 1.0 | NA | 1.0 | NA |
| ⩾9–<17 | 1.06 (0.77 to 1.46) | 0.74 | 1.03 (0.74 to 1.43) | 0.87 |
| ⩾17–<31 | 0.76 (0.53 to 1.07) | 0.12 | 0.76 (0.53 to 1.08) | 0.12 |
| ⩾31 | 0.94 (0.67 to 1.30) | 0.69 | 0.94 (0.67 to 1.32) | 0.74 |
| Overall p value | 0.27 | 0.33 | ||