Haemodynamic data, histopathology, and weight ratios according to peroxisome proliferator activated receptor γ treatment in rats with and without experimental autoimmune myocarditis (EAM)
| Group | No | HW:BW (mg/g) | HR (beats/min) | SBP(mm Hg) | DBP(mm Hg) | Pericardial effusion score | Microscopic score | Macroscopic score |
|---|---|---|---|---|---|---|---|---|
| Data are mean (SD). | ||||||||
| *p<0.05, **p<0.01 v Myocarditis rats. | ||||||||
| 15d-PGJ2, rats with EAM treated with 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2); Con-15d-PGJ2, normal rats treated with 15d-PGJ2; Con-PIO, normal rats treated with pioglitazone (PIO); Controls, normal rats treated with phosphate buffered saline (PBS); Con-Vehicle, normal rats treated with vehicle; DBP, diastolic blood pressure; HR, heart rate; HW:BW, ratio of heart weight to body weight; Myocarditis, rats with EAM treated with PBS; PIO, rats with EAM treated with PIO; SBP; systolic blood pressure. | ||||||||
| Healthy control rats | ||||||||
| Con-Vehicle | 7 | 2.98 (0.22) | 391 (13) | 130.3 (9.8) | 91.9 (8.7) | 0 | 0 | 0 |
| Con-15d-PGJ2 | 7 | 3.05 (0.14) | 411 (24) | 131.1 (11.1) | 92.7 (10.2) | 0 | 0 | 0 |
| Con-PIO | 7 | 3.09 (0.09) | 403 (21) | 132.5 (10.2) | 90.8 (9.8) | 0 | 0 | 0 |
| Experiment I | ||||||||
| Controls | 7 | 2.99 (0.11)** | 401 (20) | 132.5 (11.7) | 92.8 (9.1) | 0 | 0 | 0 |
| Myocarditis | 8 | 5.45 (0.57) | 432 (49) | 131.3 (10.7) | 91.5 (12.80 | 1.8 (0.4) | 3.4 (0.9) | 3.5 (1.1) |
| 15d-PGJ2 | 8 | 4.07 (0.69)** | 417 (31) | 131.8 (18.7) | 91.9 (16.9) | 0.9 (0.4)** | 1.5 (0.8)** | 1.8 (0.7)** |
| PIO | 8 | 4.19 (1.03)** | 412 (39) | 133.2 (13.8) | 92.8 (15.2) | 1.2 (0.8)* | 1.9 (0.8)** | 2.0 (0.3)** |
| Experiment II | ||||||||
| Controls | 7 | 3.07 (0.13)** | 396 (31) | 133.5 (10.7) | 93.1 (10.2) | 0 | 0 | 0 |
| Myocarditis | 8 | 5.56 (0.59) | 441 (59) | 129.3 (11.1) | 91.1 (13.2) | 1.9 (0.5) | 3.5 (1.0) | 3.6 (0.8) |
| 15d-PGJ2 | 8 | 4.41 (0.38)** | 427 (61) | 130.1 (12.7) | 92.0 (14.7) | 1.2 (0.7)* | 2.4 (0.7)* | 2.3 (0.6)** |
| PIO | 8 | 4.57 (0.63)* | 422 (49) | 131.2 (15.8) | 91.9 (16.1) | 1.3 (0.5)* | 2.7 (0.8) | 2.6 (0.4)** |