Table 1

Clinical trials of hypothermia during acute myocardial infarction

Study acronym	Design	Inclusion criteria	Cooling system	No. of patients	Target temperature	Duration of cooling	Primary end point
MACE, major adverse cardiac events; MI, myocardial infarction.
COOL-MI Pilot¹⁶	Randomised pilot study	MI <6 h	Reprieve Temperature Therapy System	42	33°C	3 h	MACE
LOW TEMP¹⁷	Registry	MI <6 h	Coolgard Temperature Management System	20	32-34°C	4 h	Infarct size
NICAMI	Registry	MI <6 h	Artic Sun Temperature Management System	11	34°C	3 h	MACE
COOL-MI¹⁸	Randomised, multicentre	MI <6 h	Reprieve Temperature Therapy System	412	33°C	3 h	Infarct size
ICE-IT¹⁹	Randomised, multicentre	MI <6 h	Celsius Control System	228	33°C	6 h	Infarct size
COOL-MI II	Non-randomised, multicentre	Anterior MI <6 h	Reprieve Temperature Therapy System	150	33°C	3 h	Infarct size