Table 1

Comparative trials (1): details of the trials comparing percutaneous coronary intervention with thrombolytic therapy

Patient characteristics		Symptom duration (h)	Number randomised to PTCA (n = 3872)	Number randomised to thrombolysis (n = 3867)	Stents used	Gp IIb/IIIa antagonists used	Thrombolytic agent used, administration time	Time to treatment (mins)
Patient characteristics		Symptom duration (h)	Number randomised to PTCA (n = 3872)	Number randomised to thrombolysis (n = 3867)	Stents used	Gp IIb/IIIa antagonists used	Thrombolytic agent used, administration time	PTCA	Thrombolysis
GP, glycoprotein; LBBB, left bundle branch block; MI, myocardial infarction; PTCA, percutaneous transluminal coronary angioplasty; t-PA, tissue plasminogen activator; USK, units of streptokinase
Streptokinase trials (n = 1837)
Zijlstra 1993	Age <75 years ST ↑	6	152	149	No	No	1.5 million USK, 1 h	62	30
Riberio 2001	Age <75 years ST ↑	6	50	50	No	No	1.2 million USK, 1 h	238	179
Grinfield 2000	ST ↑	12	54	58	No	No	1.5 million USK, 1 h	63	18
Zijlstra 1996	ST ↑ low risk	6	47	53	No	No	1.5 million USK, 1 h	68	30
Akhras	ST ↑	12	42	45	No	No	1.5 million USK, 1 h	NA	NA
Widimsky 1997	ST ↑ LBBB	6	101	99	Yes	No	1.5 million USK, 1 h	80	70
De Boer	Age >76 years ST ↑	6	46	41	Yes	No	1.5 million USK, 1 h	59	31
Widimsky 2000	ST ↑	12	429	421	Yes	Yes	1.5 million USK, 1 h	277	245
Fibrin specific trial (n = 5902)
DeWood 2000	Age ⩽76 years ST ↑	12	46	44	No	No	Duteplase, 4 h	126	84
Grines 1997	ST ↑	12	195	200	No	No	t-PA, 3 h	60	32
Gibbons 1999	Age <80 years ST ↑	12	47	56	No	No	Duteplase, 4 h	45	30
Ribichini 2002	Age <80 years, inferior MI, anterior ST ↓	6	55	55	No	No	Accelerated t-PA	40	33
Garcia 2001	Anterior MI	5	95	94	No	No	Accelerated t-PA	84	69
GUSTO IIB 2001	ST ↑ LBBB	12	565	573	No	No	Accelerated t-PA	114	72
Le May 2002	ST ↑ LBBB	12	62	61	Yes	Yes	Accelerated t-PA	77	15
Bonnefoy 2002	ST ↑	12	421	419	Yes	Yes	Accelerated t-PA	190	130
Schomig 2000	ST ↑	12	71	69	Yes	Yes	Accelerated t-PA	65	30
Vemeer 2001	Age <80 years ST ↑	6	75	75	Yes	No	Accelerated t-PA	100	85
Andersen 1997	ST ↑	12	790	782	Yes	NA	Accelerated t-PA	NA	NA
Kastrati 1995	ST ↑ LBBB	12	81	81	Yes	Yes	Accelerated t-PA	75	35
Aversano 1997	ST ↑	12	225	226	Yes	Yes	Accelerated t-PA	102	46
Grines 2000	ST ↑	12	71	66	Yes	Yes	Accelerated t-PA	155	51
Hochman 1998	Cardiogenic shock	36	52	150	Yes	Yes	Accelerated t-PA	75	168