Summary of trials assessing progression of aortic stenosis by repeated echocardiography
| Study and reference | |||||||
|---|---|---|---|---|---|---|---|
| Aronow et al16 | Novaro et al17 | Bellamy et al18 | Rosenhek et al19 | Samal et al20 | Antonini-Canterin et al21 | Cowell et al22 | |
| LDL, low density lipoprotein; NA, not available; RCT, randomised controlled trial; RO, retrospective observational study. | |||||||
| Design | RO | RO | RO | RO | RO | RO | Prospective RCT |
| Patients | 180 | 174 | 156 | 211 | 112 | 242 | 134 |
| Patients taking statin | 62 | 57 | 38 | 50 | 55 | 121 | 65 |
| Mean age (years) | 82 | 68 | 77 | 70 | 73 | 68 | 68 |
| Mean follow up (months) | 33 | 21 | 44 | 24 | NA | 54 | 25 |
| Total cholesterol (mmol/l) | NA | 5.5 | 5.8 | 5.8 | NA | NA | 5.7 |
| Correlation of progression with LDL cholesterol | NA | Yes/no | No | No | Yes | NA | No |
| Reduced progression with statin | Yes | Yes | Yes | Yes | No | No | No |