Baseline and six month cardiac structure and function of randomised participants in the SHAPE study
| Variable | Exercise (n = 51) | Control (n = 53) | p Value* | ||
|---|---|---|---|---|---|
| Baseline | 6 Months | Baseline | 6 Months | ||
| Data are mean (95% confidence interval). | |||||
| *p Values shown are for the comparison of exercisers versus controls at six months; †p<0.01 for comparison of exercisers versus controls at baseline. No other measures were different between groups at baseline. | |||||
| A, peak late diastolic filling wave velocity; Am, peak mitral annular late diastolic velocity during atrial contraction; DT, deceleration time; E, peak early diastolic filling wave velocity; Em, peak mitral annular early diastolic velocity; IRT, isovolumic relaxation time; LA, left atrial; LV, left ventricular; LVEDD, left ventricular end diastolic dimension; LVESD, left ventricular end systolic dimension; LVMI, left ventricular mass index; PWT, posterior wall thickness; RWT, relative wall thickness; Vp, propagation of mitral inflow; VST, ventricular septal thickness. | |||||
| LV size by MRI | |||||
| LV mass (g) | 125.2 (116.8 to 133.5) | 125.7 (116.7 to 134.8) | 130.1 (119.5 to 140.1) | 129.5 (119.3 to 139.7) | 0.99 |
| LVMI (g/m2) | 63.6 (60.1 to 67) | 65.1 (61.3 to 68.8) | 65.1 (60.9 to 69.4) | 65.0 (61.3 to 68.7) | 0.63 |
| LV size by echocardiography | |||||
| LVEDD (cm) | 4.7 (4.6 to 4.8) | 4.6 (4.5 to 4.8) | 4.5 (4.4 to 4.6) | 4.6 (4.4 to 4.7) | 0.21 |
| LVESD (cm) | 3.2 (3 to 3.3) | 3.0 (2.9 to 3.2) | 3.1 (2.9 to 3.2) | 3.0 (2.9 to 3.2) | 0.52 |
| VST (mm) | 1.0 (1.0 to 1.1) | 1.0 (1.0 to 1.1) | 1.1 (1.0 to 1.1) | 1.1 (1.0 to 1.1) | 0.48 |
| PWT (mm) | 1.0 (1.0 to 1.1) | 1.0 (1.0 to 1.1) | 1.1 (1.0 to 1.1) | 1.0 (1.0 to 1.1) | 0.88 |
| RWT (mm) | 0.44 (0.42 to 0.46) | 0.45 (0.43 to 0.47) | 0.47 (0.45 to 0.49)* | 0.46 (0.44 to 0.47) | 0.93 |
| LA size (cm) | 3.7 (3.6 to 3.8) | 3.7 (3.5 to 3.8) | 3.8 (3.7 to 3.9) | 3.7 (3.6 to 3.9) | 0.68 |
| LV function by Doppler echocardiography | |||||
| E (cm/s) | 74.9 (71.2 to 78.5) | 73.5 (69.5 to 77.4) | 73.8 (70.2 to 77.4) | 72.3 (68.6 to 76.9) | 0.88 |
| A (cm/s) | 81.4 (77.1 to 85.7) | 83.3 (73.2 to 93.5) | 83.4 (79.4 to 87.4) | 83.0 (78.9 to 87.1) | 0.77 |
| E:A ratio | 0.93 (0.88 to 0.99) | 0.94 (0.87 to 1.01) | 0.91 (0.85 to 0.96) | 0.89 (0.84 to 0.95) | 0.25 |
| DT (ms) | 213.1 (204.3 to 222.0) | 233.3 (219.8 to 246.9) | 225.2 (209.9 to 240.6) | 232.2 (212.2 to 252.1) | 0.58 |
| IRT (ms) | 93.6 (89.6 to 97.5) | 93.1 (88.8 to 97.5) | 90.8 (86.2 to 95.4) | 92.7 (87.3 to 98.1) | 0.71 |
| LV function by tissue Doppler and colour M mode propagation | |||||
| Em (cm/s) | 10.1 (9.4 to 10.6) | 9.9 (9.2 to 10.5) | 10.6 (9.9 to 11.4) | 9.8 (9.2 to 10.4) | 0.25 |
| Am (cm/s) | 13.4 (12.6 to 14.1) | 12.4 (11.7 to 13.1) | 13.2 (12.4 to 14.1) | 12.8 (11.9 to 13.7) | 0.35 |
| Em:Am ratio | 0.84 (0.77 to 0.90) | 0.81 (0.75 to 0.87) | 0.87 (0.80 to 0.95) | 0.79 (0.73 to 0.85) | 0.18 |
| Vp (cm/s) | 56.5 (50.1 to 62.8) | 54.3 (48.1 to 60.5) | 56.5 (51.1 to 62.8) | 53.6 (48.1 to 59.1) | 0.97 |
| E:Vp ratio | 1.5 (1.3 to 1.6) | 1.5 (1.3 to 1.7) | 1.4 (1.3 to 1.6) | 1.5 (1.3 to 1.6) | 0.98 |
| E:Em ratio | 7.8 (7.2 to 8.5) | 7.7 (7.1 to 8.3) | 7.3 (6.8 to 7.8) | 7.7 (7.1 to 8.3) | 0.6 |