Clinical, haematological, and haemodynamic variables before and after oral bosentan treatment
| Basal | End of observation | p Value | |
|---|---|---|---|
| dPAP, diastolic pulmonary arterial pressure; Hb, haemoglobin; HR, heart rate; mCWP, mean capillary wedge pressure; mPAP, mean pulmonary arterial pressure ; mSAP, mean systemic arterial pressure; 6MWT, 6-min walk test; NS, not significant; Paco2, systemic arterial CO2; Pao2, systemic arterial O2; pH, systemic arterial pH; Plts, platelets; PVRi, pulmonary vascular resistances index; PVRi/SVRi, pulmonary to systemic vascular resistances ratio; QP, pulmonary cardiac output; QP/QS, pulmonary to systemic cardiac output ratio; QS, systemic cardiac output; RA, right atrial pressure; Sat art O2, transcutaneous oxygen saturation; sPAP, systolic pulmonary arterial pressure; SVRi, systemic vascular resistances index; WCC, white cell count; WHO, World Health Organisation. | |||
| Clinical status | |||
| Sat art O2 (%) | 81 (9) | 87 (6) | <0.001 |
| HR (bpm) | 87 (14) | 81 (10) | <0.05 |
| WHO functional class | 3.1 (0.7) | 2.5 (0.7) | <0.05 |
| Exercise tolerance: 6MWT | |||
| Travelled distance (m) | 320 (108) | 394 (73) | <0.001 |
| HR at the end (bpm) | 119 (17) | 112 (24) | NS |
| Sat art O2 at the end (%) | 63 (17) | 71 (14) | <0.05 |
| Borg index | 6.5 (1.3) | 5.3 (1.8) | <0.001 |
| Heart catheterisation pressure | |||
| RA (mm Hg) | 12 (4) | 11 (3) | NS |
| sPAP (mm Hg) | 106 (28) | 105 (37) | NS |
| dPAP (mm Hg) | 52 (8) | 49 (16) | NS |
| mPAP (mm Hg) | 73 (18) | 71 (22) | NS |
| mCWP (mm Hg) | 12 (3) | 12 (4) | NS |
| mSAP (mm Hg) | 84 (14) | 83 (18) | NS |
| Blood flow | |||
| QP (l/m/m2) | 2.8 (0.9) | 4.0 (1.3) | <0.001 |
| QS (l/m/m2) | 3.4 (1.1) | 4.2 (1.4) | <0.05 |
| QP/QS | 0.9 (0.3) | 1.0 (0.3) | NS |
| Vascular resistances | |||
| PVRi (WU.m2) | 22 (12) | 14 (9) | <0.001 |
| SVRi (WU.m2) | 27 (10) | 23 (11) | <0.01 |
| PVRi/SVRi | 0.9 (0.6) | 0.6 (0.5) | <0.05 |
| Biochemistry | |||
| Packed cell volume (%) | 57 (7) | 55 (7) | NS |
| Hb (mg/l) | 180 (40) | 170 (60) | NS |
| Plts (1000/μl) | 198 (75) | 179 (67) | NS |
| WCC (1000/μl) | 7.4 (2.3) | 7.2 (2.8) | NS |
| Aspartate aminotranferase (U/l) | 24 (9) | 28 (12) | NS |
| Alanine aminotranferase (U/l) | 31 (21) | 31 (19) | NS |
| pH | 7.37 (0.05) | 7.38 (0.07) | NS |
| Pao2 (mm Hg) | 45.5 (5.2) | 50.3 (10.1) | NS |
| Paco2 (mm Hg) | 39.3 (8.6) | 38.9 (7.3) | NS |