Table 2 Diagnostic performance of low-dose, dual-source CT coronary angiography in the step-and-shoot mode for the diagnosis of significant (>50%) coronary artery stenoses
DiagnosisSensitivity (95% CI)Specificity (95% CI)PPV (95% CI)NPV (95% CI)Accuracy (95% CI)
Segment-based
Diagnostic segments97 (94 to 99)98 (97 to 99)89 (84 to 92)99 (99 to 100)98 (97 to 99)
All segments97 (94 to 99)97 (96 to 98)84 (80 to 88)99 (99 to 100)97 (96 to 98)
Vessel-based
Diagnostic segments99 (96 to 100)98 (95 to 99)96 (92 to 99)100 (98 to 100)98 (96 to 99)
All segments99 (96 to 100)96 (93 to 98)95 (90 to 98)100 (97 to 100)98 (95 to 99)
Patient-based
Diagnostic segments100 (94 to 100)96 (94 to 100)97 (90 to 100)100 (93 to 100)98 (94 to 100)
All segments100 (95 to 100)93 (82 to 98)94 (86 to 98)100 (93 to 100)97 (92 to 99)
  • All analyses were performed separately, including only the segments with diagnostic image quality and also including all segments. For the latter, the non-diagnostic segments were rated as being positive for stenosis.

  • NPV, negative predictive value; PPV, positive predictive value.