Table 4

Clinical outcomes according to the risk predictors

	PMCE		AMI		PE		CV death
	RR (95% CI)	p Value	RR (95% CI)	p Value	RR (95% CI)	p Value	RR (95% CI)	p Value
Per 1-SD increase*
RCRI	1.26 (1.10 to 1.44)	0.001	1.18 (0.88 to 1.56)	0.27	1.30 (1.13 to 1.49)	<0.001	0.53 (0.29 to 1.00)	0.05
CRP	1.74 (1.55 to 1.95)	<0.001	1.58 (1.28 to 1.93)	<0.001	1.86 (1.64 to 2.10)	<0.001	2.16 (1.32 to 3.51)	0.002
NT-proBNP	2.17 (1.91 to 2.45)	<0.001	1.55 (1.28 to 1.88)	<0.001	2.27 (1.97 to 2.62)	<0.001	2.30 (1.48 to 3.56)	<0.001
Optimal cut-off of each risk predictors†
RCRI	1.50 (1.17 to 1.91)	0.002	1.14 (0.70 to 1.86)	0.59	1.52 (1.17 to 1.96)	0.002	0.38 (0.08 to 1.71)	0.21
CRP	2.75 (2.16 to 3.45)	<0.001	2.62 (1.66 to 4.08)	<0.001	2.97 (2.28 to 3.81)	<0.001	5.38 (1.50 to 18.78)	0.010
NT-proBNP	3.89 (3.15 to 4.74)	<0.001	2.54 (1.68 to 3.79)	<0.001	4.72 (3.72 to 5.89)	<0.001	5.39 (1.86 to 15.30)	0.002
Combination of best cut-off of each predictors§
RCRI or CRP or NT-proBNP⩾ cut-off§	4.55 (3.69 to 5.52)	<0.001	3.24 (2.10 to 4.92)	<0.001	5.64 (4.49 to 6.96)	<0.001	7.71 (2.48 to 23.32)	<0.001

Investigate independent association of each risk predictors with clinical outcomes were shown as adjusted relative risk (RR) with 95% confidence intervals (CI), all three risk predictors were included in the logistic regression analysis with forward conditional method. Analysis was adjusted with all significant univariate risk factors including age and sex.
*Measured in linear values, 1-SD increase from mean corresponded to 1 to 2 for RCRI, 135 ng/l to 601 ng/l for NT-proBNP, and 2.7 mg/l to 15.1 mg/l for CRP, respectively.
†Optimal cut-off values were ⩾2 for RCRI, ⩾301 ng/l for NT-proBNP, and ⩾3.4 mg/l for CRP.
§Defined by at least two of three risk predictors are higher than cut-off values.
AMI, acute myocardial infarction; CV Death, primary cardiovascular death; PE, pulmonary oedema; PMCE, perioperative major cardiovascular event.