Platelet function profiles at baseline, 24 h and hospital discharge
| Baseline | 24 h | Discharge | |||||||
| Intensive glucose control (n=59) | Conventional glucose control (n=56) | p Value | Intensive glucose control (n=59) | Conventional glucose control (n=56) | p Value | Intensive glucose control (n=59) | Conventional glucose control (n=56) | p Value | |
| Platelet aggregation (%) | |||||||||
| ADP 5 μM | 23.2±24.3 | 23.8±24.2 | 0.89 | 15.2±15.5 | 20.3±17.8 | 0.06 | 30.3±12.8 | 40.1±18.8 | 0.01 |
| ADP 20 μM | 34.0±28.1 | 34.2±30.3 | 0.97 | 28.9±22.6 | 31.9±22.7 | 0.23 | 47.9±13.2 | 59.1±17.3 | 0.002 |
| Collagen 6 μg/ml | 25.6±30.6 | 28.3±29.8 | 0.66 | 18.3±20.4 | 25.9±24.8 | 0.11 | 34.1±21.4 | 45.5±25.8 | 0.04 |
| Epinephrine 20 μM | 18.5±22.6 | 20.2±22.9 | 0.72 | 14.1±15.4 | 19.4±17.6 | 0.07 | 30.1±16.6 | 39.3±22.0 | 0.05 |
| TRAP 25 μM | 48.8±26.3 | 44.3±30.4 | 0.42 | 41.9±24.3 | 48.3±24.4 | 0.05 | 64.1±11.2 | 69.2±12.3 | 0.03 |
| Platelet activation (%) | |||||||||
| PRI | 64.2±23.4 | 63.3±20.7 | 0.88 | 56.4±26.7 | 55.6±27.8 | 0.45 | 47.4±19.4 | 56.6±21.9 | 0.05 |
| P-selectin expression | 39.0±31.5 | 45.0±32.5 | 0.33 | 47.9±20.9 | 56.8±21.6 | 0.05 | 48.7±20.9 | 57.4±21.2 | 0.02 |
| Glycoprotein IIb/IIIa (PAC) expression | 59.0±23.2 | 59.7±22.5 | 0.88 | 32.9±25.8 | 44.7±29.1 | 0.05 | 46.6±20.4 | 55.5±23.5 | 0.04 |
PRI, platelet P2Y12 reactivity index; TRAP, thrombin receptor-activated peptide.