Inclusion criteria for patients with multiple atherothrombotic risk factors and for those with established cardiovascular disease
| Clinically evident cardiovascular disease | |
| Cerebrovascular disease | |
| Previous TIA | 696 (12%) |
| Previous ischaemic stroke | 1807 (31%) |
| Coronary heart disease | |
| Stable angina with documented CAD | 720 (12%) |
| History of multivessel PCI | 326 (6%) |
| History of multivessel CABG | 581 (10%) |
| Previous myocardial infarction | 1399 (24%) |
| Symptomatic peripheral arterial disease | |
| Current intermittent claudication and ankle–brachial index ≤0.85 | 1003 (23%) |
| History of intermittent claudication and previous intervention | 857 (17%) |
| Multiple atherothrombotic risk factors | |
| Type 1 or 2 diabetes (with drug therapy) | 1395 (84%) |
| Diabetic nephropathy | 745 (57%) |
| Ankle–brachial index <0.9 | 89 (25%) |
| Asymptomatic carotid stenosis ≥70% of luminal diameter | 115 (22%) |
| ≥1 Carotid plaque, as evidenced by intima–media thickness | 208 (49%) |
| Systolic blood pressure ≥150 mm Hg, despite therapy for at least 3 months | 793 (48%) |
| Primary hypercholesterolaemia | 1086 (71%) |
| Current smoking >15 cigarettes/day | 304 (18%) |
| Male sex and age ≥65 years or female sex and age ≥70 years | 815 (48%) |
CABG, coronary artery bypass grafting; CAD, coronary artery disease; PCI, percutaneous coronary intervention; TIA, transient ischaemic attack.