Table 1

Characteristics of included trials

StudyYearStudy designTreatment groupsNo of patientsAge (years)LDL-cholesterol (mg/dl)DiabetesAortic jet velocity (m/sec)Aortic valve area (cm2)Transaortic pressure gradient (mm Hg)Follow-up
Chan (ASTRONOMER)62010Prospective randomisedPlacebo13558±14122±29NA3.19±0.421.56±0.70Mean 23±8Median 3.5
Rosuvastatin 40 mg/day13458±13124±25NA3.16±0.421.49±0.71Mean 23±8(2.1–4.5) years
Cowell (SALTIRE)42005Prospective randomisedPlacebo7868±10133±304 (5%)3.45±0.671.02±0.41Peak 50±20Median 25
Atorvastatin 80 mg/day7768±10137±343 (4%)3.39±0.621.03±0.40Peak 48±17(7–36) months
Mohler 102007Prospective observationalNo statins2264±10110±333 (14%)NA1.22±0.25NA12 months
Statins3170±107 (18%)NA1.13±0.27NA
Moura (RAAVE)112007Prospective open labelNo treatment6074±9117±2113 (22%)3.62±0.611.20±0.35Mean 36±13Mean 73±24 weeks
Rosuvastatin 20 mg/day6173±9158±3226 (43%)3.65±0.641.23±0.43Mean 35±13
Rossebo (SEAS)52008Prospective randomisedPlacebo92967±10139±35NA3.10±0.541.27±0.46Mean 23.0±8.7Median 52.2 months
Simvastatin (40–80 mg/day) plus ezetimibe94468±9140±36NA3.09±0.551.29±0.48Mean 22.7±8.8
Antonini-Canterin122008RetrospectiveNo statins mild aortic stenosis36071±8NA82 (23%)2.3±0.2NAMean 13.1±3.2Mean 5.6±3.2 years
Statins mild aortic stenosis14171±7NA50 (36%)2.3±0.2NAMean 12.7±3.1
No statins moderate aortic stenosis21472±8NA42 (20%)3.3±0.2NAMean 26.1±5.1
Statins moderate aortic stenosis6270±8NA14 (23%)3.3±0.2NAMean 26.0±5.0
Bellamy132002RetrospectiveNo statins11878±12137±4328 (24%)3.0±0.81.20±0.35Mean 22±12Mean 3.7±2.3 years
Statins3873±11164±499 (24%)2.8±0.51.32±0.29Mean 18±7
Kuwabara142006RetrospectiveNo statins2075±5NA3 (15%)3.1±1.0NAMean 42±2931±23 months
Statins1374±5NA6 (46%)NA30±20 months
Novaro152001RetrospectiveNo statins11767±13131 (112–143)23 (20%)NA1.2 (1.0–1.4)Mean 15 (12–22)Mean 21 months
Statins5771±9128 (94–146)20 (35%)NA1.2 (1.0–1.4)Mean 15 (12–22)
Rosenhek162004RetrospectiveNo statins16169±11141±3932 (20%)3.92±0.860.84±0.23Mean 42±20Median 24±18 months
Statins5072±8145±3811 (22%)4.08±0.860.82±0.23Mean 42±18
  • LDL, low-density lipoprotein.