Hard outcomes | n (N) | Events | OR (95% CI) | p For overall effect | Heterogeneity | Egger's test p value | ||
Statins | No statins | p Value (Q statistic) | I2 | |||||
Death from any cause | 2149 (3) | 109/1082 (10.1%) | 109/1067 (10.2%) | 0.98 (0.74 to 1.30) | 0.91 | 0.33 | 9% | 0.15 |
Randomised studies | 2028 (2) | 108/1021 (10.6%) | 105/1007 (10.4%) | 1.01 (0.76 to 1.35) | 0.92 | 0.46 | 0% | |
Non-randomised studies | 121 (1) | 1/61 (1.6%) | 4/60 (6.7%) | 0.23 (0.03 to 2.15) | 0.20 | NA | NA | |
Death from cardiovascular causes (only randomised studies available) | 2297 (3) | 52/1155 (4.5%) | 64/1142 (5.6%) | 0.79 (0.54 to 1.15) | 0.22 | 0.67 | 0% | 0.70 |
Aortic valve surgery | 2418 (4) | 311/1216 (25.6%) | 327/1202 (27.2%) | 0.92 (0.76 to 1.10) | 0.35 | 0.43 | 0% | 0.99 |
Randomised studies | 2297 (3) | 306/1155 (26.5%) | 324/1142 (28.4%) | 0.91 (0.76 to 1.09) | 0.30 | 0.35 | 4% | |
Non-randomised studies | 121 (1) | 5/61 (8.2%) | 3/60 (5.0%) | 1.70 (0.39 to 7.44) | 0.48 | NA | NA |
Aortic valve stenosis progression | n (N) | Mean difference (95% CI) | p For overall effect | Heterogeneity | Egger's test p value | |
p Value (Q statistic) | I2 | |||||
Jet velocity progression (m/s per year) | 3125 (7) | −0.08 (−0.13 to −0.03) | 0.0007 | <0.00001 | 82% | 0.02 |
Randomised studies | 1827 (2) | −0.01 (−0.03 to 0.02) | 0.48 | 0.88 | 0% | |
Non-randomised studies | 1298 (5) | −0.12 (−0.18 to −0.06) | 0.0002 | <0.0001 | 81% | |
Aortic valve area decrease (sq cm/year) | 2608 (7) | −0.02 (−0.03 to 0.00) | 0.02 | 0.24 | 25% | 0.21 |
Randomised studies | 2096 (3) | 0.00 (−0.02 to 0.02) | 0.75 | 0.93 | 0% | |
Non-randomised studies | 512 (4) | −0.05 (−0.07 to −0.02) | 0.0004 | 0.90 | 0% | |
Peak aortic gradient progression (mm Hg/year) | 731 (5) | −1.76 (−3.73 to 0.21) | 0.08 | 0.05 | 57% | 0.03 |
Randomised studies | 403 (2) | 0.10 (−1.36 to 1.56) | 0.89 | 0.86 | 0% | |
Non-randomised studies | 328 (3) | −3.40 (−5.39 to −1.41) | 0.0008 | 0.46 | 0% | |
Mean aortic gradient progression (mm Hg/year) | 2413 (5) | −0.99 (−2.04 to 0.07) | 0.07 | 0.008 | 71% | 0.04 |
Randomised studies | 1962 (2) | −0.10 (−0.36 to 0.16) | 0.46 | 1.00 | 0% | |
Non-randomised studies | 451 (3) | −2.19 (−3.35 to −1.03) | 0.0002 | 0.38 | 0% |
n, number of patients; N, number of trials.