Continuous systolic blood pressure and risk for incident heart failure: multivariable-adjusted subhazard ratios
| 120 vs 100 mm Hg | 140 vs 120 mm Hg | 160 vs 140 mm Hg | ||||
| SHR (95% CI) | p Value | SHR (95% CI) | p Value | SHR (95% CI) | p Value | |
| Total (n=4408) | 1.15 (0.75 to 1.77) | 0.52 | 1.50 (1.28 to 1.76) | <0.001 | 1.39 (1.23 to 1.58) | <0.001 |
| Men (n=2066) | 1.12 (0.68 to 1.86) | 0.65 | 1.34 (1.06 to 1.68) | 0.013 | 1.38 (1.18 to 1.61) | <0.001 |
| Women (n=2342) | 1.25 (0.53 to 2.92) | 0.61 | 1.68 (1.32 to 2.14) | <0.001 | 1.47 (1.20 to 1.80) | <0.001 |
| White (n=3600) | 1.12 (0.70 to 1.80) | 0.64 | 1.51 (1.27 to 1.81) | <0.001 | 1.38 (1.21 to 1.58) | <0.001 |
| Black (n=808) | 1.60 (0.42 to 6.16) | 0.49 | 1.38 (0.90 to 2.11) | 0.14 | 1.40 (1.01 to 1.94) | 0.046 |
Functional form of systolic blood pressure: restricted cubic spline with two knots (Figure 3).
Adjustment model: cohort (Health ABC, CHS), gender (for total cohort analysis), race (white, black), age, body mass index, history of coronary heart disease, history of smoking, history of diabetes, electrocardiographic left ventricular hypertrophy, heart rate, fasting glucose, creatinine, albumin, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglyceride levels.
CI, confidence interval; HDL, high-density lipoprotein; LDL, low-density lipoprotein; SHR, subhazard ratio for incident heart failure (competing risk: death).