Accuracy of risk prediction of the different models
| C-statistics | IDI | |||
| AUC | p Value* | IDI value | p Value* | |
| In-hospital mortality | ||||
| GRACE score | 0.87 (0.75–0.99) | – | Reference | – |
| GRACE score using hs-cTn | 0.87 (0.77–0.98) | 0.840 | 0.44 | 0.662 |
| GRACE score + hs-cTn concentration | 0.87 (0.75–0.99) | 0.966 | 0.59 | 0.555 |
| GRACE score + BNP concentration | 0.88 (0.78–0.99) | 0.583 | 0.15 | 0.877 |
| One-year mortality† | ||||
| GRACE score | 0.88 (0.81–0.95) | – | Reference | – |
| GRACE score using hs-cTn | 0.88 (0.81–0.95) | 0.814 | 0.26 | 0.797 |
| GRACE score + hs-cTn concentration | 0.88 (0.81–0.95) | 0.640 | <0.01 | 0.999 |
| GRACE score + BNP concentration | 0.88 (0.81–0.95) | 0.322 | 1.90 | 0.058 |
| One-year combined of death/AMI† | ||||
| GRACE score | 0.75 (0.66–0.84) | – | Reference | – |
| GRACE score using hs-cTn | 0.76 (0.67–0.85) | 0.669 | 0.35 | 0.726 |
| GRACE score + hs-cTn concentration | 0.75 (0.66–0.84) | 0.740 | 0.35 | 0.724 |
| GRACE score + BNP concentration | 0.75 (0.67–0.84) | 0.978 | 1.25 | 0.210 |
* p versus the GRACE score.
† The simplified GRACE score was used according to Eagle et al.5
AMI, acute myocardial infarction; AUC, area under the receiver operating characteristics curve; BNP, B-type natriuretic peptide; hs-cTn, high-sensitivity cardiac troponin assay; IDI, integrated discriminative improvement.