Change in inflammatory markers soluble CD40 ligand (sCD40L), interleukin 6 (IL-6) and high-sensitivity CRP (hsCRP) following clopidogrel cessation
| Baseline (24 h before) | 24 h after | 48 h after | 1 wk after | 2 weeks after | 4 weeks after | |
| hsCRP (ng/ml) | ||||||
| Mean | 2513.7 | 2418.6 | 2410.9 | 2100.2 | 2042.8 | 1890.4 |
| 95% CI of mean | 1822 to 3205.4 | 1782 to 3055.2 | 1746.5 to 3075.3 | 1520.5 to 2679.9 | 1462.5 to 2623.1 | 1424.1 to 2356.7 |
| Median | 2006 | 1867.4 | 1796.5 | 1361 | 1721.8 | 1616.4 |
| Change in mean from baseline | −95.1 | −102.9 | −413.5 | −471 | −556 | |
| 95% CI of change in mean | −693.7 to 503.5 | −779 to 573.2 | −1095.9 to 268.9 | −1100.8 to 158.8 | −1043.7 to −68.3 | |
| Percentage change in mean from baseline | −3.8 | −4.1 | −16.5 | −18.7 | −24.8 | |
| p Value | 0.757 | 0.767 | 0.244 | 0.152 | 0.033 | |
| sCD40L (pg/ml) | ||||||
| Mean | 8.8 | 8.1 | 7.8 | 8.3 | 8.1 | 10.2 |
| 95% CI of mean | 6.2 to 11.4 | 5.9 to 10.3 | 5.7 to 9.9 | 6.9 to 9.7 | 6.6 to 9.6 | 7.7 to 12.7 |
| Median | 6.8 | 6.9 | 6.8 | 6.7 | 7.2 | 8.3 |
| Change in mean from baseline | −0.7 | −1 | −0.4 | −0.6 | 1 | |
| 95% CI of change in mean | −2.1 to 0.7 | −2.3 to 0.3 | −3.2 to 2.4 | −2.5 to 1.3 | −1 to 3 | |
| Percentage change in mean from baseline | −8.3 | −12.1 | −5.7 | −8 | 15.7 | |
| p Value | 0.347 | 0.152 | 0.765 | 0.552 | 0.32 | |
| IL-6 (pg/ml) | ||||||
| Mean | 4.5 | 3.7 | 3.8 | 2.5 | 2.6 | 2.2 |
| 95% CI of mean | 3.1 to 5.9 | 2.2 to 5.2 | 1.1 to 6.5 | 1.9 to 3.1 | 1.7 to 3.5 | 1.4 to 3 |
| Median | 2.9 | 2.5 | 2.4 | 2.3 | 2.1 | 1.4 |
| Change in mean from baseline | −0.9 | −0.7 | −2 | −2 | −2.3 | |
| 95% CI of change in mean | −2.3 to 0.5 | −3 to 1.6 | −3.3 to −0.7 | −3.7 to −0.3 | −3.7 to −0.9 | |
| Percentage change in mean from baseline | −19 | −16.2 | −45 | −43.3 | −50.8 | |
| p Value | 0.245 | 0.54 | 0.006 | 0.027 | 0.004 | |
hsCRP, high-sensitivity C-reactive protein; IL-6, interleukin 6; sCD40 L, soluble CD40 ligand.