Key parameters used in model
| Parameter | Base case analysis | Sensitivity analysis | ||
| Value | Source | Value | Source | |
| Length of stay | ||||
| Minimum hospital stay | 5 days | Expert opinion | 5 days | Expert opinion |
| Mean ICU LOS | 2 days | Expert opinion | 2 days | Literature review |
| Mean GW LOS* | 7 days | Expert opinion | 7 days | Literature review |
| Event probabilities | ||||
| Conversion to SAVR | 0.0% | 14 | 1.78% | Literature review |
| Intraoperative death | 1.1% | 14 | 1.45% | Literature review |
| Reoperation (short-term) | 1.7% | 14 | 2.36% | Literature review |
| Stroke† | 6.70% | 14 | 2.88% | Literature review |
| Bleeding† | 16.8% | 14 | 10.06% | Literature review |
| Vascular† | 30.70% | 14 | 7.52% | Literature review |
| Aortic regurgitation† | 11.80% | 14 | 23.39% | Literature review |
| Renal failure† | 1.1% | 14 | 8.87% | Literature review |
| Pacemaker implant† ‡ | 3.4% | 14 | 7.70% | Literature review |
| Unit costs | ||||
| Procedure cost (per hour) | £524.40 | 15 | ||
| Day in ICU | £1.149 | 16 | ||
| Day in non-ICU | £136 | 16 | ||
| Pacemaker implantation | £3119–£6371§ | 16 | ||
| Community-based rehabilitation | £1575 | 17 | ||
| Managed rehabilitation | £4081 | 17 | ||
↵* Literature reported information on overall LOS. Value represents the difference between overall and ICU LOS.
↵† Only applied to TAVI arm.
↵‡ 1/3 single chamber, 1/3 dual chamber, 1/3 biventricular.
↵§ Range covers the different types of pacemaker available.
GW, general ward; ICU, intensive care unit; LOS, length of stay; SAVR, standard aortic valve replacement; TAVI, transcatheter aortic valve implantation.