Table 1

Baseline characteristics

	OPG tertile 3 (%)	n	N	OPG tertiles 1 and 2 (%)	n	N	p Value
Randomisation group (ranolazine)	48.4	719	1485	49.8	1484	2978	0.37
Age ≥75 years	30.1	447	1485	9.9	296	2978	<0.001
Gender (male)	59.1	878	1485	67.7	2017	2978	<0.001
Race (Caucasian)	96.7	1436	1485	96.8	2882	2978	0.89
BMI group
BMI <25 kg/m²	24.6	361	1465	18.5	545	2943	<0.001
BMI 25–<30 kg/m²	41.0	600	1465	43.6	1283	2943
BMI ≥30 kg/m²	34.4	504	1465	37.9	1115	2943
Index diagnosis
Unstable angina	41.1	611	1485	53.1	1582	2978	<0.001
NSTEMI	56.7	842	1485	44.1	1312	2978
Other	2.2	32	1485	2.8	84	2978
Increased glucose^*	7.9	66	836	5.4	113	2112	0.009
History of diabetes	42.4	629	1485	27.8	827	2978	<0.001
History of hypertension	77.5	1145	1478	73.1	2165	2960	0.0018
History of dyslipidaemia	63.5	847	1334	69.9	1899	2715	<0.001
Current smoker	19.6	291	1485	27.9	829	2976	<0.001
History of CHF	23.3	346	1485	19.5	582	2978	0.0036
Family history of CAD	33.3	443	1330	42.9	1205	2812	<0.001
Prior angina	58.9	847	1438	59.8	1755	2933	0.55
Prior myocardial infarction	35.5	521	1466	36.0	1062	2954	0.79
Prior PCI	19.7	291	1475	20.8	618	2965	0.39
Prior CABG	13.1	194	1483	11.2	332	2977	0.060
Creatinine clearance <60 ml/min	33.2	490	1478	13.7	407	2969	<0.001
TIMI risk score							<0.001
0–2	17.2	255	1485	28.2	839	2978
3–4	53.7	798	1485	53.6	1597	2978
≥5	29.1	432	1485	18.2	542	2978
Aspirin^†	95.6	1420	1485	96.8	2882	2978	0.05
Clopidogrel	65.3	970	1485	62.2	1852	2978	0.041
Beta blocker	89.7	1332	1485	90.4	2692	2978	0.46
ACE-I or ARB	81.3	1208	1485	76.8	2286	2978	0.0005
Statin	78.2	1162	1485	79.0	2352	2978	0.57

↵* Fasting glucose >7.0 mmol/l (126 mg/100 ml) or non-fasting glucose ≥11.1 mmol/l (200 mg/100 ml).
↵† During hospitalisation or at discharge.
ACE-I, ACE inhibitor; ARB, angiotensin receptor blocker; BMI, body mass index; CABG, coronary artery bypass graft; CAD, coronary artery disease; CHF, congestive heart failure; NSTEMI, non-ST elevation myocardial infarction; OPG, osteoprotegerin; PCI, percutaneous coronary intervention; TIMI, Thrombolysis in Myocardial Infarction.