Table 2

Osteoprotegerin and the severity of structural heart disease

	OPG tertile 3 (%)	n cases	N total	OPG tertiles 1 and 2 (%)	n cases	N total	p Value
BNP >80 ng/l	56.7	842	1484	35.6	1060	2978	<0.001
TnI ultra positive (≥40 ng/l)	73.1	1069	1463	60.4	1787	2959	<0.001
Disease extent (≥50%)^*
None	10.4	84	807	12.1	202	1669	<0.001
One VD	22.6	182	807	31.4	524	1669
Two VD	25.5	206	807	24.0	400	1669
Three VD or LM	41.5	335	807	32.5	543	1669
LVEF (<50%)^†	45.7	454	994	35.3	706	2000	<0.001

↵* Among 2476 patients with angiographic data available.
↵† Among 2994 patients with LVEF available.
BNP, B type natriuretic peptide; LM, left main; LVEF, left ventricular ejection fraction; OPG, osteoprotegerin; TnI, troponin I; VD, vessel disease.