Hazard ratios (95% CI) for thromboembolism and death according to weekly alcohol intake for women with incident atrial fibrillation
| Alcohol intake, drinks* per week | |||||
|---|---|---|---|---|---|
| Abstainers | <7 (reference) | 7 to 13 | 14 to 20 | >20 | |
| Subjects, n | 45 | 601 | 229 | 110 | 123 |
| Thromboembolism or death | |||||
| VKA adjusted† | 0.90 (0.46 to 1.76) | 1 | 0.94 (0.67 to 1.32) | 1.20 (0.78 to 1.83) | 1.08 (0.68 to 1.70) |
| Multi adjusted‡ | 0.76 (0.38 to 1.50) | 1 | 1.06 (0.74 to 1.50) | 1.25 (0.82 to 1.92) | 1.23 (0.78 to 1.96) |
| Frequency adjusted§ | 0.70 (0.35 to 1.40) | 1 | 1.30 (0.85 to 2.01) | 1.66 (0.96 to 2.86) | 1.71 (0.93 to 3.14) |
| Thromboembolism | |||||
| VKA adjusted | 0.75 (0.18 to 3.13) | 1 | 1.03 (0.56 to 1.91) | 0.77 (0.30 to 1.97) | 1.53 (0.73 to 3.17) |
| Multi adjusted | 0.66 (0.16 to 2.79) | 1 | 1.14 (0.61 to 2.13) | 0.77 (0.301.98) to | 1.71 (0.81 to 3.60) |
| Frequency adjusted | 0.68 (0.16 to 2.94) | 1 | 1.45 (0.68 to 3.11) | 1.11 (0.37 to 3.28) | 2.78 (1.02 to 7.60) |
| Death | |||||
| VKA adjusted | 0.84 (0.39 to 1.81) | 1 | 0.93 (0.63 to 1.37) | 1.24 (0.77 to 1.98) | 0.97 (0.57 to 1.64) |
| Multi adjusted | 0.72 (0.33 to 1.55) | 1 | 1.06 (0.72 to 1.57) | 1.29 (0.80 to 2.08) | 1.10 (0.64 to 1.89) |
| Frequency adjusted | 0.65 (0.30 to 1.42) | 1 | 1.29 (0.79 to 2.10) | 1.65 (0.89 to 3.03) | 1.44 (0.72 to 2.87) |
Thromboembolism: includes ischaemic stroke or peripheral arterial thromboembolism. Measures of association in bold indicates statistical significance.
*One drink equates to 12 g of pure alcohol.
†Calculated using Cox's regression with time since atrial fibrillation diagnosis as underlying time variable and adjusted for VKA treatment.
‡Further adjustment for CHA2DS2-VASc components.
§Also adjusted for frequency of intake (not weekly, non-daily or daily).
VKA, vitamin K antagonist.