Individual and multivariable regression analysis of clinical and CMR variables for the prediction of left ventricular reverse remodelling
| Variables | Univariate analysis | Multivariable analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| B Coefficient±SD | R2 | 95% CI | p Value | B Coefficient±SD | t | 95% CI | p Value | |
| EDVI (ml/m2) | ||||||||
| EDVI | 0.57±0.12 | 0.32 | 0.33 to 0.81 | <0.001 | 0.53±0.1 | 4.56 | 0.29 to 0.76 | <0.001 |
| TAVI procedure | 15.5±3.8 | 0.50 | 7.9 to 23.1 | <0.001 | 10.43±3.7 | 2.78 | 2.8 to 18 | 0.008 |
| CAD | 11.5±4.3 | 0.42 | 3.0 to 20.1 | 0.009 | 1.87±4.1 | 0.45 | −6.5 to 10.2 | 0.65 |
| Hypercholesterolaemia | 11.9±4.1 | 0.43 | 3.7 to 20.2 | 0.005 | 6.41±3.7 | 1.73 | −1.1 to 13.9 | 0.09 |
| PVD | 14.4±6.2 | 0.39 | 1.8 to 26.9 | 0.03 | 6.31±4.9 | 1.28 | −3.6 to 16.3 | 0.20 |
| AR (%) | 0.34±0.19 | 0.38 | 0.39 to 0.71 | 0.08 | 0.3±0.1 | 2.18 | 0.02 to 0.57 | 0.04 |
| Scar (%) | 2.01±0.34 | 0.68 | 1.31 to 2.70 | <0.001 | 1.25±0.3 | 3.79 | 0.58 to 1.91 | 0.001 |
| ESVI (ml/m2) | ||||||||
| ESVI | 0.44±0.08 | 0.63 | 0.28 to 0.59 | <0.001 | 0.21±0.06 | 3.20 | 0.07 to 0.34 | 0.003 |
| TAVI procedure | 8.12±2.8 | 0.49 | 2.4 to 13.8 | 0.006 | 3.50±2.5 | 1.37 | −1.6 to 8.6 | 0.17 |
| CAD | 5.23±3.1 | 0.44 | −0.97 to 11.4 | 0.09 | 1.66±2.6 | 0.65 | −3.5 to 6.8 | 0.52 |
| AF | 8.97±4.3 | 0.45 | 0.25 to 17.7 | 0.04 | 5.29±3.3 | 1.59 | −1.4 to 11.9 | 0.12 |
| PVD | 10.6±4.2 | 0.47 | 2.1 to 19.2 | 0.02 | 7.05±3.3 | 2.12 | 0.35 to 13.7 | 0.04 |
| Scar (%) | 1.61±0.3 | 0.71 | 1.0 to 2.20 | <0.001 | 1.30±0.2 | 5.43 | 0.81 to 1.78 | <0.001 |
| EF (%) | ||||||||
| EF | 0.49±0.8 | 0.66 | 0.33 to 0.65 | <0.001 | 0.51±0.08 | 6.78 | 0.36 to 0.66 | <0.001 |
| MPG | 0.14±0.05 | 0.53 | 0.05 to 0.23 | 0.005 | 0.14±0.05 | 2.98 | 0.05 to 0.23 | 0.005 |
| LVMI (g/m2) | ||||||||
| LVMI | 0.64±0.07 | 0.67 | 0.51 to 0.77 | <0.001 | 0.69±0.07 | 9.88 | 0.55 to 0.83 | <0.001 |
| NYHA | 4.66±2.5 | 0.74 | 0.48 to 9.81 | 0.07 | 4.3±2.5 | 1.74 | −0.73 to 9.34 | 0.09 |
| CVA | 3.77±2.2 | 0.69 | −0.71 to 8.24 | 0.09 | 3.66±2.2 | 1.69 | −0.72 to 8.05 | 0.1 |
Individual variables with a significance level of p<0.1 were entered in to the multivariable model. Each parameter of change had a separate multiple regression analysis performed.
AR, aortic regurgitation; CAD, coronary artery disease; CMR, cardiovascular magnetic resonance; CVA, cerebrovascular accident; EDVI, end diastolic volume indexed to body surface area; EF, ejection fraction; ESVI, end systolic volume indexed; LVEF, left ventricular ejection fraction; LVM, left ventricular mass; MF, myocardial fibrosis; MPG, mean pressure gradient; NYHA, New York Health Association; PVD, peripheral vascular disease; SAVR, surgical aortic valve replacement; SVI, stroke volume indexed; TAVI, transcatheter aortic valve implantation.