Baseline value | 18 month value | Slope (%/month) | p Value (within group) | p Value (between groups) | |
---|---|---|---|---|---|
Total cholesterol (mmol/L) | |||||
Statins+placebo | 4.5±1.1 | 4.0±0.7 | −0.6% (0.1) | <0.001 | 0.84 |
Statins+niacin | 4.4±0.9 | 3.9±0.7 | −0.6% (0.1) | <0.001 | |
LDL (mmol/L) | |||||
Statins+placebo | 2.4±0.8 | 2.0±0.5 | −0.8% (0.2) | <0.001 | 0.14 |
Statins+niacin | 2.3±0.7 | 1.8±0.5 | −1.1% (0.2) | <0.001 | |
HDL (mmol/L) | |||||
Statins+placebo | 1.5±0.4 | 1.4±0.4 | −0.3% (0.1) | 0.007 | <0.001 |
Statins+niacin | 1.5±0.4 | 1.6±0.4 | 0.4% (0.1) | <0.001 | |
Triglycerides (mmol/L) | |||||
Statins+placebo | 1.5±0.9 | 1.3±0.6 | −0.4% (0.3) | 0.10 | 0.03 |
Statins+niacin | 1.5±0.9 | 1.0±0.4 | −1.3% (0.3) | <0.001 | |
non-HDL (mmol/L) | |||||
Statins+placebo | 3.1±1.1 | 2.6±0.6 | −0.7% (0.2) | <0.001 | 0.047 |
Statins+niacin | 2.9±0.9 | 2.3±0.6 | −1.2% (0.2) | <0.001 | |
TC/HDL ratio | |||||
Statins+placebo | 3.3±1.2 | 3.0±0.7 | −0.3% (0.1) | 0.02 | <0.001 |
Statins+niacin | 3.2±0.9 | 2.5±0.5 | −1.0% (0.1) | <0.001 |
Means± SD. LDL denotes low density lipoprotein cholesterol. HDL denotes high density lipoprotein cholesterol. TC denotes total cholesterol. All values log-transformed for analysis of slopes over time; slopes presented as percent change per month.