Comparison of endpoints across studies
| Bassiouny et al15 | Bernard et al23 | Haines et al16 | Ichiki et al24 | Kaseno et al17 | Kim et al18 | Lakkireddy et al9 | Maddox et al19 | Mendoza et al25 | Nin et al20 | Pavaci et al26 | Rowley et al.27 | Snipelisky et al21 | Yamaji et al22 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Minor bleeding | 7/376 D 16/623 W Groin haematoma 5/ 376 D 10/ 623 W GI bleed 1/376 D 2/623 W Minor haemoptysis 1 /623 W Epistaxis1/623 W PEff without tamponade 1/376 D 2/623 W | 1/155 D 2/44 W | 4/ 222 D 2/ 222 W Minor bleeding complications 2/ 222 D 1/ 222 W Vascular complication 2/222 D 1/222 W | NA | 5/110 D 11/101 W Groin haematoma 5/110 D 11/101 W | 5/191 D 19/572 W Groin haematoma 4/191 D 19/572 W PEff without tamponade 1/191 D | 12/145 D 8/145 W Groin haematoma 6/145 D 5/145 W PEff without tamponade 6/145 D 4/145 W | 1/212 D 3/251 W Groin haematoma 1/212 D 2/251 W Minor haemoptysis 1/251 W | 1/60 D 1/58 W Groin haematoma 1/58 W GI bleed 1/60 D | 9/45 D 20/45 W Rebleeding from puncture site 9/45 D 20/45 W | 2/27 D 4/27 W Groin haematoma 2/27 D 4/27 W | 5/113 D 33/169 W Non-life threatening vascular complications 5/113 D 33/169 W | 6/31 D 21/125 W Haematoma 1/31 D 4/125 W Rebleeding 5/31 D 10/125 W Ecchymosis 7/125 W | 2/106 D 11/397 W Groin haematoma 1/106 D 4/397 W PEff without tamponade 1/106 D 7/397 W |
| Major bleeding | 4/376 D 8/623 W PEff with need of pct 3/ D 7/ W Haemoptysis* 1/ W Cerebral bleeding 1/ D† | 2/155 D 2/44 W | 3/222 D 3/222 W PEff with need of pct 2/222 D 2/222 W Other major bleeding 1/222 D 1/222 W | 4/30 D 4/180 W PEff with need of pct 4/30 D 4/180 W | 0/110 D 2/101 W Cardiac tamponade 2/101 W | 4/191 D 12/572 W Cardiac tamponade 2/191 D 7/572 W Vascular complications 2/191 D 5/572 W | 9/145 D 1/145 W Cardiac tamponade 9/145 D 1/145 W | 1/212 D 3/251 W Cardiac tamponade 1/212 D 2/251 W Retroperitoneal haematoma 1/251 W | 0 | 0 | 0 | 0/113 D 1/169 W Retroperitoneal bleed 1/169 W | 0 | 0/106 D 4/397 W Cardiac tamponade 4/397 W |
| Thrombo-embolism | 1/376 D 1/623 W Stroke 1/623 W Pulmonary embolism 1/376 D | 0 | 2/222 D ‡ 0/222 W Stroke 1/222 D TIA 1/222 D | 0 | 0 | 0 | 3/145 D 0/145 W Stroke or TIA 3/145 D | 1/212 D 0/251 TIA 1/212 D | 0/60 D 1/58 W Stroke 1/58 W | 0/45 D 1/45 W Mesenteric thrombosis 1/45 W | 1/27 D 0/27 W Stroke 1/27 D | 2/113 D 2/169 W Stroke 1/113 D 1/169 W TIA 1/113 D Pulmonary embolism 1/169 W | 0 | 0 |
*Requiring transfusion.
†Patient with a cerebral cavernous malformation.
‡The patients with stroke stopped dabigatran 36 h before the procedure and the patient with TIA restarted the drug only 17 h after the procedure.
D, dabigatran; GI, gastrointestinal; NA, data not available; pct, pericardiocentesis; PEff, pericardial effusion; punct, puncture; TIA, transient ischaemic attack; W, warfarin.