Table 3

Univariate and multivariate Cox regression survival analysis for the primary endpoint (all-cause mortality)

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	p Value	HR	95% CI	p Value
Age, per year	1.079	1.048 to 1.112	<0.001	1.064	1.032 to 1.098	<0.001
Male sex	1.194	0.635 to 2.246	0.582
Ischaemic aetiology	1.684	0.963 to 2.944	0.068
Atrial fibrillation	1.373	0.823 to 2.290	0.224
Diabetes	1.705	0.963 to 3.018	0.067
ICD system (versus PM)	0.897	0.507 to 1.589	0.710
Percentage of pacing, per %	1.007	1.002 to 1.013	0.006	1.008	1.002 to 1.015	0.008
LVEDV, per mL	1.005	1.002 to 1.009	0.001
LVESV, per mL	1.007	1.004 to 1.011	<0.001
LVEF, per %	0.968	0.946 to 0.990	0.005	0.973	0.947 to 0.999	0.041
Mitral regurgitation grade 0 (reference group)			0.028			0.510
Mitral regurgitation grade 1 (vs reference group)	0.449	0.219 to 0.922		1.185	0.522 to 2.691
Mitral regurgitation grade 2 (vs reference group)	0.840	0.409 to 1.727		1.445	0.626 to 3.336
Mitral regurgitation grade 3 (vs reference group)	1.815	0.737 to 4.468		2.067	0.695 to 6.146
Mitral regurgitation grade 4 (vs reference group)	2.695	0.632 to 11.483		2.634	0.662 to 10.488
RV end-diastolic area, per mm²	1.069	1.025 to 1.114	0.002
RV fractional area change, per %	0.975	0.953 to 0.996	0.022
TAPSE, per mm	0.914	0.856 to 0.976	0.007	0.974	0.910 to 1.042	0.447
Right atrial diameter, per mm	1.412	1.071 to 1.861	0.014
Tricuspid annular diameter, per mm	1.748	1.325 to 2.306	<0.001
sPAP, per mm Hg	1.046	1.029 to 1.063	<0.001
Significant lead-induced TR	1.687	1.023 to 2.780	0.040	1.749	1.008 to 3.035	0.047

Bold values are statistically significant.
ICD, implantable cardioverter-defibrillator; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular EF; LVESV, left ventricular end-systolic volume; PM, permanent pacemaker; sPAP, systolic pulmonary arterial pressure; TAPSE, tricuspid annular plane systolic excursion; TR, tricuspid regurgitation.