Table 4

Univariate and multivariate Cox regression survival analysis for the secondary endpoint (all-cause mortality and heart failure related events)

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	p Value	HR	95% CI	p Value
Age, per year	1.039	1.018 to 1.061	<0.001	1.026	1.003 to 1.050	0.030
Male sex	0.908	0.557 to 1.481	0.699
Ischaemic aetiology	1.632	1.035 to 2.575	0.035	1.040	0.602 to 1.797	0.887
Atrial fibrillation	1.058	0.683 to 1.639	0.801
Diabetes	1.277	0.777 to 2.098	0.335
ICD device and lead	1.283	0.764 to 2.155	0.347
Percentage of pacing, per %	1.003	0.999 to 1.008	0.157	1.001	0.996 to 1.007	0.636
LVEDV, per mL	1.006	1.003 to 1.008	<0.001
LVESV, per mL	1.008	1.005 to 1.011	<0.001
LVEF, per %	0.958	0.939 to 0.977	<0.001	0.971	0.949 to 0.994	0.013
Mitral regurgitation grade 0 (reference group)			0.011			0.014
Mitral regurgitation grade 1 (vs reference group)	0.511	0.277 to 0.943		1.175	0.618 to 2.235
Mitral regurgitation grade 2 (vs reference group)	1.042	0.572 to 1.896		1.345	0.687 to 2.633
Mitral regurgitation grade 3 (vs reference group)	2.371	1.081 to 5.201		2.659	1.126 to 6.276
Mitral regurgitation grade 4 (vs reference group)	0.915	0.124 to 6.732		6.559	1.861 to 23.116
RV end-diastolic area, per mm²	1.048	1.011 to 1.086	0.010
RV fractional area change, per %	0.966	0.949 to 0.984	<0.001
TAPSE, per mm	0.913	0.864 to 0.963	0.001	0.971	0.917 to 1.028	0.307
Right atrial diameter, per mm	1.355	1.082 to 1.699	0.008
Tricuspid annular diameter, per mm	1.509	1.204 to 1.892	<0.001
sPAP, per mm Hg	1.059	1.042 to 1.075	<0.001
Significant lead-induced TR	1.641	1.087 to 2.480	0.019	1.649	1.043 to 2.599	0.032

Bold values are statistically significant.
ICD, implantable cardioverter-defibrillator; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular EF; LVESV, left ventricular end-systolic volume; sPAP, systolic pulmonary arterial pressure; TAPSE, tricuspid annular plane systolic excursion; TR, tricuspid regurgitation.