Impact of BNP level on event-free survival in patients with severe AS (n=157)
| Individual | Multivariate models #1 | Multivariate models #2 | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Resting BNP level | ||||||
| Resting BNP level (per 100 pg/mL increase) | 1.5 (1.2 to 1.8) | <0.0001 | 1.4 (1.1 to 1.8) | 0.007 | – | – |
| Peak-exercise BNP level | ||||||
| Peak-exercise BNP level (per 100 pg/mL increase) | 1.5 (1.4 to 1.7) | <0.0001 | 1.4 (1.2 to 1.7) | <0.0001 | – | – |
| Tertiles of peak-exercise BNP level* | ||||||
| Tertile 1 (6 to 46 pg/mL) | 1.0 (referent) | – | 1.0 (referent) | – | 1.0 (referent) | – |
| Tertile 2 (47 to 94 pg/mL) | 2.6 (1.4 to 5.0) | 0.0003 | 2.9 (1.5 to 5.7) | 0.002 | 2.8 (1.4 to 5.7) | 0.003 |
| Tertile 3 (95 to 956 pg/mL) | 6.1 (3.2 to 11.4) | <0.0001 | 5.3 (2.6 to 10.8) | <0.0001 | 5.0 (2.3 to 11.0) | <0.0001 |
| Resting BNP level (per 100 pg/mL increase) | 1.5 (1.2 to 1.8) | <0.0001 | – | – | 1.1 (0.7 to 1.5) | 0.75 |
| δ Of BNP levels | ||||||
| Absolute difference of BNP levels (per 100 pg/mL increase from rest) | 3.6 (2.6 to 4.9) | <0.0001 | – | – | 3.4 (2.2 to 5.3) | <0.0001 |
| Resting BNP level (per 100 pg/mL increase) | 1.5 (1.2 to 1.8) | <0.0001 | – | – | 1.0 (0.7 to 1.3) | 0.95 |
| Tertiles of δ BNP levels | ||||||
| Tertile 1 (−54 to 4) | 1.0 (referent) | – | 1.0 (referent) | – | 1.0 (referent) | – |
| Tertile 2 (4 to 20) | 2.5 (1.3 to 5.7) | 0.0006 | 3.1 (1.4 to 6.9) | 0.006 | 3.0 (1.2 to 6.2) | 0.008 |
| Tertile 3 (20 to 337) | 8.4 (4.1 to 17.1) | <0.0001 | 7.7 (3.4 to 17.4) | <0.0001 | 7.1 (3.1 to 16.1) | <0.0001 |
| Resting BNP level (per 100 pg/mL increase) | 1.5 (1.2 to 1.8) | <0.0001 | – | – | 1.2 (0.9 to 1.6) | 0.12 |
Models #1 included age, gender, mean transvalvular gradient, valvulo-arterial impedance, indexed left atrial area, and exercise-induced increases in heart rate, mean transvalvular gradient, and valvulo-arterial impedance; Models #2 were Models #1 plus resting BNP level.
*The boundaries of the peak-exercise BNP tertiles in the severe AS are slightly different from those in the whole cohort presented in tables 1 and 2.
AS, aortic stenosis; BNP, B-type natriuretic peptide.