Haemodynamic features according to SVI in LG severe aortic stenosis with preserved EF
| Group 1 (SVI <38 mL/m2) | Group 2 (SVI 38–43 mL/m2) | Group 3 (SVI 43–48 mL/m2) | Group 4 (SVI ≥48 mL/m2) | p Value | |
|---|---|---|---|---|---|
| Heart rate (bpm) | 79±14 | 71±12* | 66±10*† | 64±9*† | <0.001 |
| Systolic blood pressure (mm Hg) | 126±20 | 128±19 | 130±20 | 127±20 | 0.41 |
| Diastolic blood pressure (mm Hg) | 69±12 | 68±12 | 67±9 | 65±11* | 0.04 |
| EF (%) | 61±7 | 64±7* | 64±5* | 65±6* | <0.001 |
| LV end diastolic dimension (mm) | 45.8±0.5 | 45.7±0.5 | 46.8±0.5 | 46.0±0.5 | 0.33 |
| LV end systolic dimension (mm) | 29.6±0.5 | 28.7±0.5 | 29.1±0.5 | 28.4±0.5 | 0.31 |
| Relative wall thickness | 0.51±0.10 | 0.46±0.10* | 0.48±0.08 | 0.47±0.09* | 0.01 |
| LV mass index (g/m2) | 101±29 | 97±24 | 105±23 | 105±25 | 0.06 |
| SVI (mL/m2) | 33±3 | 41±1* | 45±1*† | 52±3*†‡ | <0.001 |
| Zva (mm Hg/mL/m2) | 4.6±0.9 | 3.9±0.5* | 3.6±0.5* | 3.2±0.5*†‡ | <0.001 |
| SAC (mL mm Hg−1 m−2) | 0.66±0.20 | 0.74±0.22 | 0.79±0.26* | 0.91±0.35*†‡ | <0.001 |
| SVR (dyn s cm−5) | 1369±349 | 1319±307 | 1306±277 | 1265±282 | 0.12 |
| AV area (cm2) | 0.87±0.10 | 0.89±0.08 | 0.91±0.07* | 0.90±0.08 | 0.04 |
| AV area index (cm2/m2) | 0.45±0.06 | 0.48±0.05* | 0.49±0.05* | 0.53±0.06*†‡ | <0.001 |
| AV peak velocity (m/s) | 3.6±0.4 | 3.7±0.3* | 3.8±0.3*† | 3.8±0.3*† | <0.001 |
| AV mean LG (mm Hg) | 30±6 | 33±4* | 33±5* | 34±4*† | <0.001 |
| LV outflow tract diameter (cm) | 2.1±0.2 | 2.1±0.1 | 2.1±0.2 | 2.1±0.2 | 0.81 |
| Medial E/e′ | 18±11 | 18±9 | 16±7 | 19±10 | 0.47 |
| Right ventricular systolic pressure (mm Hg) | 39±13 | 39±13 | 38±13 | 41±13 | 0.50 |
Values are mean±SD or number (%). Pairwise comparisons were performed with a post hoc Bonferroni test (p<0.008).
*Significant difference (p<0.05) with group 1.
†Significant difference with group 2.
‡Significant difference with group 3.
AV, aortic valve; LG, low-gradient; SAC, systemic arterial compliance; SVI, stroke volume index; SVR, systemic vascular resistance; Zva, valvuloarterial impedance.