Incidence rate and HR of SCD in relation to BMI categories in ARIC, stratified by smoking status
| BMI categories | ||||||
|---|---|---|---|---|---|---|
| <18.5 | 18.5–24.9 | 25–29.9 | 30–34.9 | 35+ | P for trend | |
| Non-smokers (n=11 036) | ||||||
| N | 44 | 3282 | 4463 | 2130 | 1117 | |
| SCD cases | 0 | 21 | 67 | 36 | 26 | |
| Person-years | 533 | 42 394 | 56 973 | 26 796 | 14 006 | |
| SCD incidence* | 0 | 0.41 | 0.75 | 0.87 | 1.55 | |
| Model 1 HR† | 0 | 1 (ref) | 1.73 (1.06 to 2.84) | 1.94 (1.12 to 3.33) | 3.36 (1.85 to 6.07) | 0.0001 |
| Model 2 HR‡ | 0 | 1 (ref) | 1.27 (0.77 to 2.10) | 1.06 (0.60 to 1.87) | 1.46 (0.78 to 2.76) | 0.41 |
| Current smokers (n=3905) | ||||||
| N | 88 | 1607 | 1424 | 580 | 206 | |
| SCD cases | 3 | 43 | 38 | 17 | 2 | |
| Person-years | 970 | 19 186 | 17 382 | 7133 | 2486 | |
| SCD incidence* | 1.92 | 1.37 | 1.19 | 1.35 | 0.49 | |
| Model 1 HR† | 1.39 (0.43 to 4.50) | 1 (ref) | 0.86 (0.55 to 1.33) | 0.94 (0.53 to 1.65) | 0.34 (0.08 to 1.41) | 0.25 |
| Model 2 HR‡ | 1.82 (0.55 to 6.03) | 1 (ref) | 0.66 (0.42 to 1.04) | 0.60 (0.33 to 1.09) | 0.16 (0.04 to 0.69) | 0.003 |
*Per 1000 person-year. Adjusted for age, sex, and race.
†Model 1: Cox proportional hazard model adjusted for age, sex and race, field centre, education level.
‡Model 2: Model 1+ adjustment for SBP, antihypertensive medication use, diabetes, LDLc, HDLc, triglycerides, prevalent CHD, prevalent heart failure, resting heart rate on ECG and LVH at baseline ECG.ARIC, Atherosclerosis Risk in Communities; BMI, body mass index; CHD, coronary heart disease; HDLc, high density lipoprotein cholesterol; LDLc, low density lipoprotein cholesterol; LVH, LV hypertrophy; SBP, systolic blood pressure; SCD, sudden cardiac death.