Parameters for long-term extrapolation
| Parameter | Mean value |
|---|---|
| Annual risk of MI in the no event state | 0.019 |
| Annual risk of stroke in the no event state | 0.003 |
| Risk of death in the no event state* | 2.00 |
| Risk of death in the non-fatal MI state* | 6.00 |
| Risk of death in the post-MI state* | 3.00 |
| Risk of death in the non-fatal stroke state* | 7.43 |
| Risk of death in the poststroke state* | 3.00 |
| Cost in the non-fatal MI state (€)† | 15 656 (5836, 9558, 2971) |
| Cost in the post-MI state (€)† | 4172 (332, 3421, 792) |
| Cost in the non-fatal stroke state (€)† | 12 977 (15 262, 14 925, 1527) |
| Cost in the poststroke state (€)† | 3506 (4237, 4336, 413) |
| Cost in the no-event state (€)† | 1376 (253, 719, 243) |
| QALY weight in the non-fatal state age<69 years | 0.8737 |
| QALY weight in the non-fatal state age 70–79 years | 0.8130 |
| QALY weight in the non-fatal state age >79 years | 0.7537 |
| QALY decrement non-fatal MI state | 0.0755 |
| QALY decrement post-MI state | 0.0755 |
| QALY decrement non-fatal stroke state | 0.1034 |
| QALY decrement post-stroke state | 0.1034 |
*HR versus standard mortality.
†Values for the UK, Germany and Brazil shown in parentheses.
MI, myocardial infarction; QALY, quality-adjusted life-year.