Main characteristics of included studies
| PCI strategies subgroups, n | ||||||||
|---|---|---|---|---|---|---|---|---|
| Primary author, year published | Period | Setting | Patients or lesions | FFR threshold | Angiography- guided PCI | FFR-guided PCI | Exclusion criteria | Maximum follow-up |
| Prospective studies | ||||||||
| Frohlich, 2014 | 2004.01-2011.07 | Multicentre | All patients treated by PCI | N/A | 37 090 | 2767 | STEMI | 3.3 years |
| Koo, 2008 | 2004.06-2006.01 | N/A | Coronary bifurcation lesions with jailed side branches after DES implantation at the main branches | <0.75 | 110 | 110 | STEMI, LM, totally occluded lesion | 9 months |
| Pijls, 2010 | 2006.01-2007.09 | Multicentre | MVD | ≤0.80 | 496 | 509 | LM, previous CABG, cardiogenic shock, extremely tortuous or calcified coronary arteries | 2 years |
| Wongpraparut, 2005 | 2000.10-2002.08 | Single-centre | Stable angina, MVD | <0.75 | 80 | 57 | Previous CABG, totally occluded vessels, recent MI | 30 months |
| Retrospective studies | ||||||||
| Di Serafino, 2013 | 2000.01-2011.06 | N/A | Stable or unstable angina, intermediate stenosis in bypass grafts | ≤0.80 | 158 | 65 | STEMI, NSTEMI | 3.8 years |
| Li, 2013 | 2002.10-2009.12 | N/A | Patients referred for coronary revascularisation | <0.75 | 6268 | 1090 | STEMI, cardiogenic shock, referral for CABG | 50.9 months |
| Puymirat, 2012 | 2004.01-2008.12 | Single-centre | Stable or unstable angina, small vessels | <0.80 | 495 | 222 | Patients treated with PCI and stenting for a concomitant large vessel, bypass graft stenting, STEMI, NSTEMI, PCI performed without stent implantation | 3.3 years |
CABG, coronary artery bypass graft surgery; DES, drug eluting stent; FFR, fractional flow reserve; LM, left main stenosis; MI, myocardial infarction; MVD, multivessel disease; N/A, not available; NSTEMI, non-ST-segment elevation myocardial infarction; PCI, percutaneous coronary intervention; STEMI, ST-segment elevation myocardial infarction.