Baseline characteristics of the overall population overall and according to terciles of progression of aortic valve calcification (AVC)
| Overall n=149 | Terciles of AVC progression | ||||
|---|---|---|---|---|---|
| First tercile (<85 AU/year) | Second tercile (85–205 AU/year) | Third tercile (>206 AU/year) | p Value | ||
| Age, years | 74±9 | 73±9 | 75±8 | 75±10 | 0.2 |
| Body surface area, m2 | 1.9±0.2 | 1.9±0.2 | 1.8±0.2 | 1.9±0.2 | 0.1 |
| Male gender | 112 (75) | 35 (70) | 35 (71) | 42 (84) | 0.2 |
| Sinus rhythm | 138 (93) | 48 (96) | 45 (92) | 45 (90) | 0.5 |
| Diabetes | 32 (21) | 9 (18) | 14 (29) | 9 (18) | 0.34 |
| Hypertension | 102 (69) | 32 (64) | 33 (67) | 37 (74) | 0.55 |
| Smoker | 80 (54) | 26 (52) | 27 (55) | 27 (54) | 0.95 |
| Trileaflet aortic valve | 125 (84) | 43 (86) | 43 (88) | 39 (78) | 0.4 |
| Total cholesterol | 4.76±1.10 | 4.78±1.21 | 4.60±0.98 | 4.90±1.09 | 0.36 |
| Low-density lipoprotein cholesterol | 2.67±0.94 | 2.73±0.97 | 2.43±0.86 | 2.84±0.95 | 0.06 |
| Serum creatinine (μmol/L) | 92±29 | 97±36 | 87±21 | 92±28 | 0.67 |
| Calcium (mmol/L) | 2.37±0.12 | 2.37±0.13 | 2.38±0.12 | 2.36±0.11 | 0.35 |
| Phosphate (mmol/L) | 1.06±0.17 | 1.08±0.18 | 1.08±0.15 | 1.02±0.18 | 0.26 |
| EF, % | 63±5 | 63±6 | 63±6 | 63±4 | 0.5 |
| Baseline aortic valve area, cm2 | 1.41±0.36 | 1.57±0.38 | 1.38±0.36 | 1.29±0.30 | 0.0007 |
| Baseline indexed aortic valve area, cm2/m2 | 0.75±0.18 | 0.82±0.19 | 0.75±0.19 | 0.68±0.15 | 0.0007 |
| Baseline MPG, mm Hg | 22±11 | 17±9 | 20±6 | 29±13 | <0.0001 |
| Baseline peak aortic velocity, cm/s | 299±62 | 270±55 | 290±41 | 338±68 | <0.0001 |
| Baseline AVC score, AU | 1108±891 | 775±761 | 825±459 | 1717±1020 | <0.0001 |
| Mean MPG increase, mm Hg/year | 3±3 | 1±1 | 3±2 | 5±4 | <0.0001 |
| Mean AVC increase, AU/year | 188±176 | 45±25 | 138±35 | 379±175 | <0.0001 |
Results are mean±SD or number of patients (percentage).
AU, arbitrary unit; AVC, aortic valve calcification; MPG, mean pressure gradient.