Thrombin generation parameters and corresponding odds ratios for stent thrombosis
| 0 pM TF+ASIS | 1 pM TF+thrombomodulin | 5 pM TF | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p Value | Adjusted OR (95% CI) | p Value | OR (95% CI) | p Value | Adjusted OR (95% CI) | p Value | OR (95% CI) | p Value | Adjusted OR (95% CI) | p Value | |
| Peak height* | 3.1 (1.1 to 9.5) | 0.041 | 3.8 (1.0 to 13.6) | 0.044 | 3.3 (1.1 to 9.7) | 0.033 | 3.3 (1.0 to 10.8) | 0.049 | 4.7 (1.6 to 14.0) | 0.006 | 4.9 (1.4 to 17.8) | 0.015 |
| Velocity index | 3.8 (1.3 to 11.3) | 0.019 | 4.8 (1.3 to 17.3) | 0.018 | 2.8 (0.9 to 8.2) | 0.068 | 2.1 (0.6 to 6.8) | 0.240 | 5.6 (1.8 to 17.2) | 0.002 | 5.3 (1.5 to 19.1) | 0.010 |
| ETP† | 2.6 (0.8 to 8.1) | 0.105 | 2.8 (0.8 to 10.7) | 0.124 | 3.3 (1.1 to 9.7) | 0.033 | 3.5 (1.1 to 11.7) | 0.042 | 1.1 (0.3 to 3.4) | 0.920 | 0.5 (0.1 to 2.3) | 0.397 |
| Lag time | 9.9 (2.8 to 35.0) | 0.001 | 17.5 (3.3 to 91.1) | 0.001 | 2.8 (0.9 to 8.2) | 0.068 | 3.2 (1.0 to 10.4) | 0.058 | 1.6 (0.6 to 4.5) | 0.380 | 2.0 (0.6 to 6.7) | 0.243 |
| Time to peak | 9.9 (2.8 to 35.0) | <0.001 | 36.0 (4.0 to 327.9) | 0.001 | 3.9 (1.3 to 11.6) | 0.015 | 4.5 (1.4 to 14.8) | 0.013 | 2.1 (0.7 to 6.2) | 0.160 | 2.7 (0.8 to 9.0) | 0.117 |
| Time to tail | 36.7 (4.5 to to 300.6) | 0.001 | 100.9 (7.1 to 1800.7) | 0.001 | 2.8 (0.9 to 8.2) | 0.068 | 4.0 (1.2 to 14.0) | 0.029 | 4.1 (1.4 to 12.2) | 0.011 | 4.1 (1.2 to 14.4) | 0.026 |
*Peak height (0 and 1 pM TF) or normalised peak height (5 pM TF).
†ETP (0 pM TF), ETP reduction (1 pM TF with thrombomodulin) or normalised ETP (5 pM TF). Presented are the unadjusted and adjusted ORs with 95% CIs. Adjustment was performed for the potential confounders hypertension, smoking, stent length and culprit vessel (baseline characteristics with a p value ≤0.1 in χ2 tests).
ASIS, active site-inhibited factor VIIa; ETP, endogenous thrombin potential; TF, tissue factor.