Range (g/day) | Total | Quintile 1 0 | Quintile 2 0.6–3.5 | Quintile 3 4.1–7.0 | Quintile 4 7.2–15.5 | Quintile 5 15.6–98.8 | p Linearity |
---|---|---|---|---|---|---|---|
CHD/n (%) | 2434/20 951 (11.6) | 577/4195 (13.8) | 564/4437 (12.7) | 437/4035 (10.8) | 449/4106 (10.9) | 407/4178 (9.7) | |
Model 1 | 1.00 | 0.97 (0.86 to 1.09) | 0.97 (0.86 to 1.10) | 0.87 (0.77 to 0.99) | 0.85 (0.75 to 0.96) | 0.003 | |
Model 2 | 1.00 | 1.01 (0.90 to 1.13) | 1.01 (0.89 to 1.15) | 0.91 (0.80 to 1.03) | 0.88 (0.77 to 1.01) | 0.024 | |
Model 3 | 1.00 | 1.03 (0.91 to 1.15) | 1.03 (0.91 to 1.17) | 0.92 (0.81 to 1.05) | 0.91 (0.80 to 1.04) | 0.06 | |
1754/16 162 (10.9) | 435/3251 (13.4) | 407/3406 (11.9) | 307/3102 (9.9) | 325/3220 (10.1) | 280/3183 (8.8) | ||
Model 4a | 1.00 | 1.00 (0.87 to 1.15) | 0.98 (0.85 to 1.14) | 0.88 (0.76 to 1.01) | 0.83 (0.71 to 0.97) | 0.006 | |
Model 4b | 1.00 | 1.00 (0.87 to 1.14) | 0.98 (0.84 to 1.13) | 0.87 (0.75 to 1.01) | 0.82 (0.70 to 0.97) | 0.005 | |
Stroke/n (%) | 848/20 951 (4.0) | 226/4195 (5.4) | 187/4437 (4.2) | 139/4035 (3.4) | 165/4106 (4.0) | 131/4178 (3.1) | |
Model 1 | 1.00 | 0.83 (0.68 to 1.00) | 0.84 (0.68 to 1.04) | 0.85 (0.70 to 1.04) | 0.77 (0.62 to 0.96) | 0.036 | |
Model 2 | 1.00 | 0.85 (0.70 to 1.03) | 0.87 (0.70 to 1.07) | 0.86 (0.70 to 1.06) | 0.77 (0.62 to 0.97) | 0.046 | |
Model 3 | 1.00 | 0.86 (0.71 to 1.05) | 0.87 (0.71 to 1.08) | 0.88 (0.71 to 1.07) | 0.78 (0.63 to 0.98) | 0.06 | |
648/16 162 (4.0) | 168/3251 (5.2) | 149/3406 (4.4) | 100/3102 (3.2) | 132/3220 (4.1) | 99/3183 (3.1) | ||
Model 4a | 1.00 | 0.95 (0.76 to 1.18) | 0.87 (0.67 to 1.12) | 0.94 (0.74 to 1.18) | 0.81 (0.62 to 1.05) | 0.14 | |
Model 4b | 1.00 | 0.95 (0.76 to 1.18) | 0.87 (0.67 to 1.11) | 0.94 (0.74 to 1.18) | 0.80 (0.62 to 1.05) | 0.14 |
Model 1 adjusted for sex and age.
Model 2 adjusted for sex, age, smoking, physical activity, energy intake and alcohol consumption.
Model 3: as model 2 and diabetes, body mass index, systolic blood pressure, LDL cholesterol and HDL cholesterol.
Model 4a: as model 3, but restricted to number of participants for whom CRP is available (N=16 162).
Model 4b: as model 3 and CRP (N=16 162).CHD, coronary heart disease; CRP, C-reactive protein; EPIC, European Prospective Investigation into Cancer; HDL, high density lipoprotein; LDL, low density lipoprotein.