Lean wild-type | Obese wild-type | Obese transgenic | p Value (obese) | |
---|---|---|---|---|
Weight (g) | 30.3 ± 0.5 | 45.0 ± 1.2 | 42.4 ± 1.0 | 0.2 |
Fasting glucose (mmol/l) | 4.5 ± 0.2 | 7.6 ± 0.6 | 6.3 ± 0.3 | 0.07 |
Peak glucose at GTT (mmol/l) | 9.5 ± 0.9 | 17.1 ± 1.0 | 13.3 ± 0.5 | 0.002 |
Trough glucose at ITT (mmol/l) | 3.8 ± 0.1 | 5.3 ± 0.3 | 4.3 ± 0.3 | 0.02 |
Systolic pressure (mm Hg) | 102 ± 3.6 | 122 ± 1.7 | 108 ± 4.8 | 0.01 |
Insulin blunting of max vasoconstriction (%) | 32 ± 3.1 (p<0.001) | 6 ± 5.7 (p = 0.36) | 21 ± 8.6 (p<0.05) |
GTT, glucose tolerance test; ITT, insulin tolerance test.