Sensitivity analysis of factors associated with major cardiovascular events in 217 patients (overall missing data in 73/290 patients in regards to secondary prophylaxis in 63 cases and ethnicity in 10 cases)
| Factor | Multivariate HR (95% CI) | Multivariate p value |
|---|---|---|
| Mild RHD | 1 | <0.001 |
| Moderate RHD | 3.22 (0.90 to 11.49) | |
| Severe RHD | 11.07 (3.21 to 38.22) | |
| ARF vs no ARF | 0.54 (0.25 to 1.14) | 0.10 |
| Sex (male) | 0.82 (0.47 to 1.45) | 0.50 |
| Melanesian | 1.07 (0.54 to 2.13) | 0.84 |
| Age group | ||
| 5–20 years | 1 | 0.31 |
| 21–40 years | 1.97 (0.79 to 4.92) | |
| >40 years | 2.10 (0.72 to 6.10) | |
| Ongoing secondary prophylaxis at FU | 0.33 (0.14 to 0.79) | 0.013 |
ARF, acute rheumatic fever; FU, follow-up; RHD, rheumatic heart disease.