Characteristics | QResearch derivation cohort | THIN validation cohort | ||
New users of statins | Non-users of statins | New users of statins | Non-users of statins | |
Total | 225922 (100.00) | 1778770 (100.00) | 282056 (100.00) | 1923840 (100.00) |
Female | 104774 (46.38) | 909423 (51.13) | 129085 (45.77) | 988038 (51.36) |
Male | 121148 (53.62) | 869347 (48.87) | 152971 (54.23) | 935802 (48.64) |
Age, mean (SD) | 57.2 (11.7) | 44.4 (13.7) | 59.2 (11.8) | 46 (13.9) |
Ethnicity | ||||
Ethnicity recorded | 121355 (53.72) | 569466 (32.01) | 54627 (19.37) | 303572 (15.78) |
White/not recorded | 215077 (95.20) | 1699991 (95.57) | 275014 (97.50) | 1873857 (97.40) |
Indian | 2861 (1.27) | 13398 (0.75) | 2153 (0.76) | 10793 (0.56) |
Pakistani | 1658 (0.73) | 7562 (0.43) | 776 (0.28) | 3430 (0.18) |
Bangladeshi | 679 (0.30) | 3226 (0.18) | 262 (0.09) | 1224 (0.06) |
Other Asian | 759 (0.34) | 7321 (0.41) | 809 (0.29) | 5930 (0.31) |
Caribbean | 1788 (0.79) | 9853 (0.55) | 982 (0.35) | 4849 (0.25) |
Black African | 834 (0.37) | 15358 (0.86) | 609 (0.22) | 8967 (0.47) |
Chinese | 316 (0.14) | 4015 (0.23) | 151 (0.05) | 2206 (0.11) |
Other ethnic group | 1950 (0.86) | 18046 (1.01) | 1300 (0.46) | 12584 (0.65) |
BMI and smoking | ||||
BMI recorded | 207644 (91.91) | 1341863 (75.44) | 255544 (90.60) | 1444453 (75.08) |
Smoking status recorded | 224982 (99.58) | 1615527 (90.82) | 279998 (99.27) | 1758891 (91.43) |
BMI and smoking status recorded | 207494 (91.84) | 1330320 (74.79) | 255310 (90.52) | 1433122 (74.49) |
Body mass index, mean (SD) | 28.3 (4.9) | 26 (4.6) | 28.3 (4.9) | 26.1 (4.6) |
Non-smoker | 109406 (48.43) | 912149 (51.28) | 115122 (40.82) | 795944 (41.37) |
Ex-smoker | 74277 (32.88) | 285271 (16.04) | 99446 (35.26) | 253294 (13.17) |
Current smoker (amount not recorded) | 2286 (1.01) | 55859 (3.14) | 10376 (3.68) | 239225 (12.43) |
Current smoker (light) | 14447 (6.39) | 116035 (6.52) | 15406 (5.46) | 120385 (6.26) |
Current smoker (moderate) | 13880 (6.14) | 142469 (8.01) | 20494 (7.27) | 186825 (9.71) |
Current smoker (heavy) | 10686 (4.73) | 103744 (5.83) | 19154 (6.79) | 163218 (8.48) |
Townsend score, mean (SD) | −0.5 (3.3) | −0.3 (3.4) | −0.5 (3.1) | −0.7 (3.1) |
Comorbidity | ||||
Atrial fibrillation | 11656 (5.16) | 13730 (0.77) | 13951 (4.95) | 15149 (0.79) |
Congestive cardiac failure | 7457 (3.30) | 9026 (0.51) | 8802 (3.12) | 9707 (0.50) |
Cardiovascular disease | 56943 (25.20) | 31038 (1.74) | 77244 (27.39) | 33838 (1.76) |
Treated hypertension | 97782 (43.28) | 106582 (5.99) | 107572 (38.14) | 99559 (5.18) |
Chronic kidney disease 3b+ | 18768 (8.31) | 17114 (0.96) | 19156 (6.79) | 13032 (0.68) |
Type 1 diabetes | 2843 (1.26) | 2633 (0.15) | 3829 (1.36) | 2945 (0.15) |
Type 2 diabetes | 47703 (21.11) | 18243 (1.03) | 58860 (20.87) | 18348 (0.95) |
Rheumatoid arthritis | 3652 (1.62) | 11762 (0.66) | 5155 (1.83) | 14660 (0.76) |
Corticosteroids | 13868 (6.14) | 44517 (2.50) | 16816 (5.96) | 50505 (2.63) |
Hypothyroidism | 12378 (5.48) | 30357 (1.71) | 17675 (6.27) | 38441 (2.00) |
Clinical values | ||||
Systolic blood pressure, mean (SD) | 141.1 (19.1) | 129.9 (19.1) | 140.7 (19.1) | 130.4 (19.2) |
LFT recorded at baseline/before statins | 131354 (58.14) | 162207 (9.12) | 135793 (48.14) | 90162 (4.69) |
LFT recorded at follow-up | 193586 (85.69) | 594750 (33.44) | 224024 (79.43) | 578686 (30.08) |
Creatine kinase recorded at baseline/before statins | 15724 (6.96) | 8642 (0.49) | 13651 (4.84) | 4807 (0.25) |
Creatine kinase recorded at follow-up | 62706 (27.76) | 43333 (2.44) | 57400 (20.35) | 42062 (2.19) |
BMI, body mass index; LFT, liver function test.