Variable | HR (75th relative to 25th centile) | Observed 25th and 75th quartiles | p Value | C-statistic |
Univariate model | ||||
BNP (pg/ml) | 2.10 | 73–458 | <0.001 | 0.648 |
MR-proANP (pmol/l) | 2.57 | 191–487 | <0.001 | 0.735 |
Copeptin (pmol/l) | 2.83 | 8–32 | <0.001 | 0.670 |
Troponin T (ng/ml) | 2.14 | <0.01–0.03 | <0.001 | 0.666 |
Multivariate model | ||||
BNP (pg/ml) | 1.88 | 73–458 | 0.002 | 0.679 |
MR-proANP (pmol/l) | 2.38 | 191–487 | <0.001 | 0.758 |
Copeptin (pmol/l) | 2.56 | 8–32 | <0.001 | 0.740 |
Troponin T (ng/ml) | 2.24 | <0.01–0.03 | <0.001 | 0.709 |
Biomarkers were added separately to the multivariate model which included NYHA class, history of myocardial infarction, and presence of biventricular pacemaker. Models were fitted using natural log transformations of all continuous variables.
BNP, B-type natriuretic peptide; MR-proBNP, midregional proatrial natriuretic peptide.