Table 2

Univariate and multivariate analysis investigating associations between subject characteristics and MR-proADM levels

	Univariate regression analysis			Multivariate regression analysis
	Standardised coefficient	p Value	r²	Standardised coefficient	p Value
Age (years)	0.44	<0.001	0.20	0.32	<0.001
Female gender	−0.06	0.019	<0.01	−0.12	<0.001
Smoking/quit smoking <1 year	0.12	<0.001	<0.01	0.18	<0.001
BMI (kg/m²)	0.26	<0.001	0.07	0.16	<0.001
Systolic BP (mm Hg)	0.24	<0.001	0.06
Diastolic BP (mm Hg)	0.16	<0.001	0.03
Heart rate (bpm)	0.05	<0.001	<0.01	0.03	0.014
Myocardial infarction	0.50	<0.001	0.01
Cerebrovascular accident	0.52	0.008	<0.01
Hypertension	0.53	<0.001	0.06
Hypercholesterolaemia	0.38	<0.001	0.03
Diabetes mellitus	0.76	<0.001	0.02	0.23	0.016
Glucose (mmol/l)	0.19	<0.001	0.03
Total cholesterol (mmol/l)	0.17	<0.001	0.03
HDL cholesterol (mmol/l)	−0.10	<0.001	0.01
Triglycerides (mmol/l)	0.15	<0.001	0.02
C reactive protein (mg/l)	0.19	<0.001	0.04
NT-proBNP (ng/l)	0.22	<0.001	0.05	0.12	<0.001
UAE (mg/24 h)	0.15	<0.001	0.02
Cystatin-C (mg/l)	0.27	<0.001	0.09	0.15	<0.001
eGFR (ml/min/1.73 m²)	−0.31	<0.001	0.10

Dependent factor: mid-regional portion of pro-adrenomedullin (MR-proADM).
BMI, body mass index; BP, blood pressure; eGFR, estimated glomerular filtration rate; HDL cholesterol, high-density lipoprotein cholesterol; NT-proBNP, N-terminal pro-brain-type natriuretic peptide; UAE, urinary albumin excretion.