Predictors of reduction in LVEF (multiple R2=0.39, p<0.001) and MWS (multiple R2=0.51, p<0.001) from baseline to the last study visit
| Reduction in EF | Reduction in MWS | |||
|---|---|---|---|---|
| Independent variables | ß | p Value | ß | p Value |
| Male sex | 0.13 | <0.001 | 0.05 | 0.02 |
| Age (years) | 0.02 | 0.42 | 0.09 | <0.001 |
| Heart rate (bpm) | 0.08 | 0.001 | 0.03 | 0.14 |
| Active study treatment | 0.03 | 0.25 | 0.03 | 0.12 |
| Reduction in ELI (cm2/m2) | −0.03 | 0.24 | 0.003 | 0.87 |
| Presence of aortic regurgitation | 0.01 | 0.68 | −0.01 | 0.81 |
| Presence of mitral regurgitation | 0.05 | 0.02 | 0.01 | 0.76 |
| LV hypertrophy | 0.12 | <0.001 | 0.06 | 0.006 |
| Concentric LV geometry | −0.04 | 0.11 | 0.04 | 0.13 |
| Baseline EF (%) | 0.60 | <0.001 | −0.03 | 0.20 |
| Baseline MWS (%) | −0.03 | 0.37 | 0.76 | <0.001 |
ELI, energy loss index; MWS, midwall shortening.