Multivariable Cox regression analysis of risk factors for all cardiac events
| Model 1* | Model 2† | Model 3‡ | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p Value | HR | 95% CI | p Value | HR | 95% CI | p Value | |
| History of VT/Vf | 3.16 | 1.26 to 7.89 | 0.014 | 2.83 | 1.03 to 6.67 | 0.044 | 2.96 | 1.06 to 6.98 | 0.037 |
| QTc interval (per 10 ms increments) | 1.01 | 1.00 to 1.01 | 0.063 | 1.04 | 0.97 to 1.11 | 0.324 | 1.04 | 0.97 to 1.12 | 0.270 |
| LVEDVI (per 10 mL/m2 increments) | 1.01 | 1.00 to 1.01 | 0.001 | 1.07 | 1.02 to 1.12 | 0.004 | 1.08 | 1.03 to 1.12 | 0.012 |
| Presence of LGE | 1.96 | 1.01 to 3.78 | 0.046 | ||||||
| SBPR <40 mm Hg | 1.93 | 1.02 to 3.65 | 0.042 | ||||||
| LGE-negative+SBPR <40 mm Hg | 2.62 | 0.77 to 10.19 | 0.122 | ||||||
| LGE-positive+SBPR ≥40 mm Hg | 2.26 | 0.69 to 8.65 | 0.179 | ||||||
| LGE-positive+SBPR <40 mm Hg | 4.05 | 1.41 to 14.55 | 0.008 | 2.08 | 1.06 to 4.11 | 0.034 | |||
*Multivariable Cox model selected by a stepwise method with factors that were significant in the univariable analysis and established risk factors for prognosis (age, gender, NYHA class, peak VO2, VE/VCO2 slope).
†Model with the combination of LGE and SBPR, adjusted for predictors selected by Model 1.
‡Best predictive model, adjusted for significant predictors selected by a stepwise Cox regression analysis based on Models 1 and 2.
EDVI, end-diastolic volume index; LGE, late gadolinium enhancement; NYHA, New York Heart Association; peak VO2, peak oxygen uptake; SBPR, systolic blood pressure response; VE/VCO2 slope, regression slope relating minute ventilation to carbon dioxide output; Vf, ventricular fibrillation; VT, ventricular tachycardia.