Unadjusted and adjusted a competing risk Cox proportional hazards regression models depicting the cardiac time intervals as predictors of future major adverse cardiovascular outcome (MACE) (n=1915)
| Harrell's c-statistics | Univariable | Model 1 Multivariable adjustment | Model 2 Multivariable adjustment | ||||
|---|---|---|---|---|---|---|---|
| SHR (95% CI) | p Value | SHR (95% CI) | p Value | SHR (95% CI) | p Value | ||
| IVRT per 10 ms increase | 0.62 | 1.20 (1.16 to 1.25) | <0.001 | 1.07 (1.02 to 1.11) | 0.003 | 1.06 (1.00 to 1.13) | 0.091 |
| IVCT per 10 ms increase | 0.57 | 1.19 (1.11 to 1.28) | <0.001 | 1.09 (1.01 to 1.18) | 0.018 | 1.07 (0.98 to 1.17) | 0.135 |
| ET per 10 ms decrease | 0.57 | 1.13 (1.08 to 1.18) | <0.001 | 1.06 (1.00 to 1.11) | 0.043 | 1.03 (0.97 to 1.10) | 0.326 |
| IVRT/ET per 0.1 increase | 0.64 | 1.44 (1.31 to 1.58) | <0.001 | 1.16 (1.08 to 1.26) | <0.001 | 1.16 (1.01 to 1.34) | 0.035 |
| IVCT/ET per 0.1 increase | 0.59 | 1.71 (1.46 to 2.02) | <0.001 | 1.31 (1.09 to 1.57) | 0.004 | 1.21 (0.98 to 1.49) | 0.074 |
| MPI per 0.1 increase | 0.64 | 1.41 (1.33 to 1.50) | <0.001 | 1.16 (1.08 to 1.24) | <0.001 | 1.13 (1.03 to 1.24) | 0.013 |
Harrell's c-statistics were calculated for the univariable models. Model 1 is adjusted for age, gender, BMI, eGFR, heart rate, hypertension, diabetes, smoking status, atrial fibrillation, ischaemic heart disease, previous ischaemic stroke and heart medication. Model 2 is adjusted for the same variables as model 1 and for systolic dysfunction determined by LVEF<50%, LAVI, LVMI, diastolic dysfunction defined by E/A ratio and DT (DT<140 ms and E/A<50 years>2.5, E/A50–70 years>2 or E/A>70 years>1.5) and E/e′.
A, peak transmitral late diastolic inflow velocity; BMI, body mass index; DT, deceleration time of early diastolic inflow; e′, average peak early diastolic longitudinal mitral annular velocity determined by colour TDI; E, peak transmitral early diastolic inflow velocity; eGFR, estimated glomerular filtration rate; ET, ejection time; IVCT, isovolumic contraction time; IVRT, isovolumic relaxation time; LAVI, left atrium volume index; LVMI, LV mass index; MPI, myocardial performance index; SHR, subdistribution HR; TDI, tissue Doppler imaging.