Circulating cytokines and other inflammatory indices in the KD group and controls
| Healthy controls Median (range) N=49 | All patients with KD Median (range) N=90 | KD vs controls p Value (95% CI of diff) | KD CAA− Median (range) N=53 | CAA− vs controls p Value (95% CI of diff) | KD CAA+ Median (range) N=37 | CAA+ vs controls p Value (95% CI of diff) | p Value (Kruskal–Wallis)* | |
|---|---|---|---|---|---|---|---|---|
| MCP-1 (pg/mL) | 219 (112, 490) | 214 (88, 858) | p=0.48 (−32 to 15) | 208 (99, 456) | p=0.22 (−44 to 9) | 229 (88, 858) | p=0.83 (−28 to 38) | 0.36 |
| Ang1 (pg/mL) | 44 302 (6835, 62 986) | 41 120 (3212, 96 865) | p=0.51 (−5945 to 2482) | 41 220 (3212, 75 043) | p=0.81 (−5642 to 3779) | 39 452 (14 711, 96 865) | p=0.32 (−8191 to 2312) | 0.61 |
| Ang2 (pg/mL) | 2303 (1063, 7830) | 2340 (821, 9270) | p=0.61 (−255 to 424) | 2468 (821, 6373) | p=0.60 (−283 to 517) | 2285 (1023, 9270) | p=0.76 (−371 to 441) | 0.83 |
| VEGF (pg/mL) | 92 (18, 475) | 117 (11, 1469) | p=0.13 (−6 to 45) | 100 (22, 1469) | p=0.48 (−15 to 33) | 141 (11, 888) | p=0.04 (1 to 90) | 0.10 |
| TM (pg/mL) | 3.82 (2.09, 9.10) | 3.80 (1.20, 8.39) | p=0.69 (−0.67 to 0.40) | 3.69 (1.20, 7.00) | p=0.35 (−0.9 to 0.30) | 4.00 (1.70, 8.39) | p=0.68 (−0.58 to 0.8) | 0.41 |
| IL-1β (pg/mL) | 0.71 (0.04, 3.66) | 0.62 (0, 16.21) | p=0.32 (−0.28 to 0.12) | 0.65 (0, 16.21) | p=0.74 (−0.25 to 0.20) | 0.56 (0, 2.58) | p=0.13 (−0.42 to 0.07) | 0.29 |
| IL-8 (pg/mL) | 3.60 (1.56, 9.60) | 4.01 (1.57, 13.30) | p=0.19 (−0.18 to 0.9) | 4.14 (1.57, 9.30) | p=0.14 (−0.17 to 1.10) | 3.63 (2.17, 13.30) | p=0.51 (−0.40 to 0.87) | 0.34 |
| TNFα (pg/mL) | 8.52 (2.39, 21.20) | 8.94 (2.01, 51.9) | p=0.42 (−0.93 to 2.20) | 9.44 (3.26, 41.00) | p=0.35 (−0.90 to 2.62) | 8.35 (2.01, 51.90) | p=0.70 (−1.7 to 2.32) | 0.66 |
| IL-10 (pg/mL) | 3.16 (1.00, 30.40) | 3.63 (0.79, 65.40) | p=0.78 (−0.68 to 0.85) | 3.37 (0.79, 63.80) | p=0.66 (−1.02 to 0.60) | 4.23 (0.80, 65.40) | p=0.26 (−0.47 to 1.80) | 0.29 |
| IL-6 (pg/mL) | 1.80 (0.50, 6.30) | 1.78 (0.26, 13.60) | p=0.58 (−0.43 to 0.27) | 1.56 (0.67, 5.03) | p=0.14 (−0.59 to 0.10) | 2.01 (0.26, 13.60) | p=0.39 (−0.26 to 0.69) | 0.08 |
| TF (pg/mL) | 42.10 (9.20–81.30) | 39.00 (7.70–74.50) | p=0.71 (−3.40 to 6.30) | 42.10 (13.90–60.90) | p=0.49 (−3.40 to 7.50) | 39.00 (7.70–74.50) | p=0.87 (−6.30 to 5.90) | 0.67 |
All values are median (range) unless otherwise specified. Number (n) of subjects in each group who had the test performed.
*p Values from Kruskal–Wallis test comparing three groups: controls, CAA− and CAA+. 95% CI of diff: 95% CI of the difference of median. Statistically significant results are in bold.
Ang, angiopoietin; CAA, coronary artery aneurysms; IL, interleukin; KD, Kawasaki disease; MCP-1, monocyte chemoattractant protein 1; TF, tissue factor; TM, thrombomodulin; VEGF, vascular endothelial growth factor.