Change in ESAS at O2 (n=68)
| Control (n=31) | Intervention (n=37) | |||||
|---|---|---|---|---|---|---|
| Deterioration | No change | Improvement | Deterioration | No change | Improvement | |
| Frequency (%) | ||||||
| Pain | 10 (32.3%) | 11 (35.5%) | 10 (32.3%) | 8 (21.6%) | 15 (40.5%) | 14 (37.8%) |
| Tiredness | 11 (35.5%) | 10 (32.3%) | 10 (32.3%) | 7 (18.9%) | 13 (35.1%) | 17 (45.9%) |
| Nausea | 1 (3.2%) | 30 (96.8%) | 0 (0.0%) | 1 (2.7%) | 34 (91.9%) | 2 (5.4%) |
| Depression* | 11 (35.5%) | 15 (48.4%) | 5 (16.1%) | 7 (18.9%) | 13 (35.1%) | 17 (45.9%) |
| Anxiety | 8 (25.8%) | 16 (51.6%) | 7 (22.6%) | 8 (21.6%) | 13 (35.1%) | 16 (43.2%) |
| Drowsiness | 3 (9.7%) | 25 (80.6%) | 3 (9.7%) | 1 (2.7%) | 31 (83.8%) | 5 (13.5%) |
| Loss of appetite | 10 (32.3%) | 9 (29.0%) | 12 (38.7%) | 7 (18.9%) | 16 (43.2%) | 14 (37.8%) |
| Sense of well-being | 14 (45.2%) | 10 (32.3%) | 7 (22.6%) | 14 (37.8%) | 9 (24.3%) | 14 (37.8%) |
| Dyspnoea* | 10 (32.3%) | 12 (38.7%) | 9 (29.0%) | 7 (18.9%) | 7 (18.9%) | 23 (62.2%) |
| Total* | 12 (41.4%) | 5 (17.2%) | 12 (41.4%) | 7 (18.9%) | 3 (8.1%) | 27 (73.0%) |
Tests using χ2; *p<0.05.
Note: the MCID cut-offs for improvement/deterioration of each symptom27 and total28 were: pain 1.4/−1, tiredness 1.5/−1.5, nausea 1.6/−2.3, depression 1/−1.8, anxiety 1.7/−1.4, drowsiness 0.8/−2, loss of appetite 1.2/−2.1, sense of well-being 1.2/−0.8, dyspnoea 1.2/−1.3 and total 5.7/−2.9.
ESAS, Edmonton Symptom Assessment Scale; MCID, minimal clinically important difference.