Results for patients with high cardiovascular risk
| Outcome | Studies (n) | Events (n) | Patients (n) | Summary effect (95% CI) | Heterogeneity (I2), % | Subgroup effect (p Value) |
|---|---|---|---|---|---|---|
| Patients with high cardiovascular risk | ||||||
| All-cause mortality | 4 | 29 | 1230 | RR 0.54 (0.26 to 1.14) | 0% | 0.13 |
| Cardiovascular mortality | 2 | 13 | 754 | RR 0.25 (0.02 to 2.66) | 49% | n.c. |
| Myocardial infarction | ||||||
| Fatal or non-fatal | 1 | 22 | 532 | RR 0.20 (0.07 to 0.57) | – | n.c. |
| Fatal | 1 | 1 | 532 | RR 0.30 (0.01 to 7.22) | – | n.c. |
| Non-fatal | 1 | 21 | 532 | RR 0.21 (0.07 to 0.61) | – | n.c. |
| Stroke | ||||||
| Fatal or non-fatal | 2 | 7 | 754 | OR 0.38 (0.09 to 1.70) | 0% | n.c. |
| Fatal | 2 | 1 | 754 | OR 7.26 (0.14 to 365.85) | – | n.c. |
| Non-fatal | 2 | 6 | 754 | OR 0.23 (0.05 to 1.17) | 0% | n.c. |
| Heart failure | ||||||
| Fatal or non-fatal | 1 | 3 | 222 | RR 0.14 (0.01 to 2.69) | – | n.c. |
| Fatal | 1 | 1 | 222 | RR 0.33 (0.01 to 7.95) | – | n.c. |
| Non-fatal | 1 | 2 | 222 | RR 0.20 (0.01 to 4.05) | – | n.c. |
| Hospitalisation | 0 | – | – | – | – | – |
| Cardiovascular intervention | 1 | 9 | 222 | RR 0.79 (0.22 to 2.85) | – | n.c. |
| Adverse event, any | 0 | – | – | – | – | – |
| Adverse event, gastrointestinal | 2 | 62 | 501 | RR 2.41 (1.43 to 4.06) | 0% | n.c. |
n.c., not calculated; OR, Peto's OR; RR, relative risk.